Featured Research

from universities, journals, and other organizations

Rats With Migraines Provide Jefferson Scientists Insights To Improved Drug Strategy

Date:
July 7, 2005
Source:
Thomas Jefferson University
Summary:
When Michael Oshinsky, Ph.D., gives his rats a headache, he has good reason. The animals are helping Dr. Oshinsky study how migraine treatments work. In recent experiments, the animals provided evidence showing that DHE, a standard drug currently used to treat acute migraine pain can also work against the onset of a phenomenon called "central sensitization," or "allodynia," which involves, as most migraine sufferers know, a heightened sensitivity to touch.

When Michael Oshinsky, Ph.D., gives his rats a headache, he has good reason.

The animals are helping Dr. Oshinsky, assistant professor of neurology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, study how migraine treatments work. In recent experiments, the animals provided evidence showing that DHE, a standard drug currently used to treat acute migraine pain can also work against the onset of a phenomenon called “central sensitization,” or “allodynia,” which involves, as most migraine sufferers know, a heightened sensitivity to touch. He presents his findings April 12, 2005 at the annual meeting of the American Academy of Neurology in Miami Beach.

For many migraine sufferers, it hurts to touch their face, brush their hair, even take a shower during a migraine attack. Triptans, another class of drugs commonly used to treat migraines, can also treat acute headache pain, but has a narrow window in which it works against allodynia. Dr. Oshinsky looked at DHE’s effectiveness on halting or lessening this secondary effect.

According to Dr. Oshinsky, putting various chemicals – “inflammatory mediators” such as bradykinins and prostaglandins – on the dura, the outside covering of the brain, causes local inflammation and activates the sensory fibers that cause pain on the dura. Neurons in a brain region called the trigeminal nucleus caudalis are then activated, setting off the sensitization process. Stimulating this pathway in the brain is a model for studying the effects of migraine drugs.

Dr. Oshinsky treated animals with DHE before, during and after giving the animals a headache. By recording the change in the activity of the neurons in the brain, he can monitor the effects of medication on the induced headache. He found that pretreating with DHE, and treating with DHE at the beginning of the induced headache prevents the headache from progressing to the debilitating sensitization state.

“Physicians have used intravenous DHE as a standard treatment for patients admitted to the hospital for their migraines,” Dr. Oshinsky notes. “The data in this new study suggest that more patients can benefit from this treatment. Since most migraine sufferers typically delay treatment until the pounding in their head has spread to their forehead or around their eyes, at this stage they don’t respond well to most treatments. These data suggest that treatment with DHE can reverse this sensitization.”

Dr. Oshinsky would like to better understand which neurotransmitters are involved in sensitization, which he hopes will lead to the development of improved migraine drugs.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Rats With Migraines Provide Jefferson Scientists Insights To Improved Drug Strategy." ScienceDaily. ScienceDaily, 7 July 2005. <www.sciencedaily.com/releases/2005/07/050706004233.htm>.
Thomas Jefferson University. (2005, July 7). Rats With Migraines Provide Jefferson Scientists Insights To Improved Drug Strategy. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2005/07/050706004233.htm
Thomas Jefferson University. "Rats With Migraines Provide Jefferson Scientists Insights To Improved Drug Strategy." ScienceDaily. www.sciencedaily.com/releases/2005/07/050706004233.htm (accessed July 26, 2014).

Share This




More Mind & Brain News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

University Quiz Implies Atheists Are Smarter Than Christians

University Quiz Implies Atheists Are Smarter Than Christians

Newsy (July 25, 2014) An online quiz from a required course at Ohio State is making waves for suggesting atheists are inherently smarter than Christians. Video provided by Newsy
Powered by NewsLook.com
Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins