Featured Research

from universities, journals, and other organizations

Gaps In Intestinal Barrier Could Cause Crohn's Disease

Date:
September 18, 2005
Source:
University of Liverpool
Summary:
Scientists at the University of Liverpool believe gaps in the intestinal barrier could be a cause of inflammatory diseases of the gut such as Crohn's disease.

LIVERPOOL, UK -- 15 September 2005: Scientists at the University ofLiverpool believe gaps in the intestinal barrier could be a cause ofinflammatory diseases of the gut such as Crohn's Disease.

Related Articles


Their research, led by Professor Alastair Watson in the University'sFaculty of Medicine, could have important implications for thetreatment of patients with diseases like Crohn's -- an inflammatorybowel disorder that causes severe ulceration in the intestine, leadingto pain, bleeding and diarrhoea.

Professor Watson's research has concentrated on the renewal ofepithelial cells in the lining of the bowel and the 'gaps' in thelining that the process leaves behind.

The human bowel is lined with millions of projections calledvilli which increase the surface area of the intestine to allow for theefficient absorption of nutrients. The villi are covered in epithelialcells which are constantly renewed -- around a thousand billion cellsare shed from the top of the villi every day.

Professor Watson and his team found that this renewal processleaves 'gaps' in the lining of the bowel which, in healthy tissue, areimmediately filled with a glue-like substance that plugs the gaps. Theresearch team, discovering these gaps for the first time, found thataround 3% of the bowel's surface area is covered in this substance. Itwas previously assumed that the lining of the intestine was acontinuous sheet of cells.

Professor Watson said: "We suspect that patients withinflammatory disease may not have the same ability to plug the gapsleft by the cell renewal process -- meaning that bacteria can seepthrough the lining of the intestine. Understanding this cell sheddingprocess may lead to new treatments for inflammatory bowel disease."

He added: "Our research may also explain the development ofcolon cancer which we believe may be down to a failure in the renewalprocess of epithelial cells. If they don't renew but amass on the wallof the gut, they may develop into a cancer -- it's an area we'll beconcentrating on in the next stage of our study."

The research, published in Gastroenterology, was carried out in collaboration with the University of Cincinnati.


Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.


Cite This Page:

University of Liverpool. "Gaps In Intestinal Barrier Could Cause Crohn's Disease." ScienceDaily. ScienceDaily, 18 September 2005. <www.sciencedaily.com/releases/2005/09/050917085509.htm>.
University of Liverpool. (2005, September 18). Gaps In Intestinal Barrier Could Cause Crohn's Disease. ScienceDaily. Retrieved March 26, 2015 from www.sciencedaily.com/releases/2005/09/050917085509.htm
University of Liverpool. "Gaps In Intestinal Barrier Could Cause Crohn's Disease." ScienceDaily. www.sciencedaily.com/releases/2005/09/050917085509.htm (accessed March 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com
Indiana Permits Needle Exchange as HIV Cases Skyrocket

Indiana Permits Needle Exchange as HIV Cases Skyrocket

Reuters - US Online Video (Mar. 26, 2015) Governor Mike Pence declares the recent HIV outbreak in rural Indiana a "public health emergency" and authorizes a short-term needle-exchange program. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins