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Gene That Controls The Severity Of Asthma Identified

Date:
September 21, 2005
Source:
Yale University
Summary:
Yale School of Medicine researchers identified a gene prevalent in the population that controls the clinical severity of asthma.
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New Haven, Conn.-Yale School of Medicine researchers identified agene prevalent in the population that controls the clinical severity ofasthma, according to their report in this week's Proceedings of theNational Academy of Sciences.

Richard Bucala, M.D., professor in the Department of InternalMedicine and senior author of the study, said that once you haveasthma, there are genes that are going to control how bad it is.

"Asthma patients who have high production variants of themacrophage migration inhibitory factor gene (MIF) are more likely tohave severe disease," he said.

Asthma is a clinical syndrome of airway inflammation,excessive response, and airflow obstruction to the lungs. Patients withasthma produce MIF, a gene product that regulates immunity, in theirserum and in the fluid that lines their lungs.

The study by Bucala and his colleagues in Dublin, Ireland,included experiments in mice that are resistant to developing asthmabecause they lack the gene, and an examination of a human population inDublin chosen for their similar ethnic and geographic identity.

When challenged with a trigger for their asthma attack, thegenetically deficient mice had less pulmonary inflammation and lowerairway hyper-responsiveness than genetically matched, wild-type controlmice. Similarly, in an analysis of 151 Caucasian patients with mild,moderate and severe asthma, there was a significant association betweenmild asthma and the low expression of MIF.

"These results support an important role for MIF in thepathogenesis of human asthma," Bucala said. "A drug treatment to lowerMIF in patients may be beneficial and could be guided by the MIFgenotype of affected individuals."

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PNAS 102: 14410-14415 (online week of Sept. 19 and in print on Oct. 4, 2005)


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The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


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Yale University. "Gene That Controls The Severity Of Asthma Identified." ScienceDaily. ScienceDaily, 21 September 2005. <www.sciencedaily.com/releases/2005/09/050921081016.htm>.
Yale University. (2005, September 21). Gene That Controls The Severity Of Asthma Identified. ScienceDaily. Retrieved May 25, 2015 from www.sciencedaily.com/releases/2005/09/050921081016.htm
Yale University. "Gene That Controls The Severity Of Asthma Identified." ScienceDaily. www.sciencedaily.com/releases/2005/09/050921081016.htm (accessed May 25, 2015).

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