Featured Research

from universities, journals, and other organizations

New Lifespan Extension Genes Found

Date:
September 30, 2005
Source:
University of California - Davis
Summary:
New genes tied to lifespan extension in yeast have been identified by researchers from UC Davis and Harvard Medical School.

Related Articles


Drasticallyreducing calorie intake, or caloric restriction, is known to extend thelifespan of species including yeast, worms and rodents. Previousresearch linked a gene called Sir2 with lifespan extension due tocaloric restriction, but worms and yeast that lack Sir2 also livelonger when put on a tough diet, showing that some other genes must beat work.

Researchers led by David Sinclair at Harvard MedicalSchool and Su-Ju Lin at UC Davis' Center for Genetics and Developmentand Section of Microbiology screened for other life-extending genes inyeast. They found a gene called Hst2 that accounts for most of thedifference.

Deleting Hst2 and Sir2 blocked most of the beneficialeffect of caloric restriction. When Hst2 was overexpressed, so that thegene was more active than normal, the yeast lived longer than normal. Athird gene, Hst1, appears to act when both Sir2 and Hst2 are missing.

Sir2and the newly identified Hst genes account for all of thelife-prolonging effects of caloric restriction in yeast, Lin said.

Inyeast, the effects of aging seem to be due to a build-up of toxiccircular DNA molecules that accidentally get copied out of ribosomalDNA, an unstable area of the yeast genome that contains hundreds ofrepeated sequences.

The researchers showed that caloricrestriction drastically reduces recombination of ribosomal DNA, andthat deleting Hst2 and Sir2 blocks this effect.

Very similargenes are found in widely different animals including worms, flies androdents. But the targets of these genes are likely to be different, asthe toxic DNA circles have not been identified in more advancedorganisms, Lin said.

The work was published in the Sept. 16 issue of Science.


Story Source:

The above story is based on materials provided by University of California - Davis. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Davis. "New Lifespan Extension Genes Found." ScienceDaily. ScienceDaily, 30 September 2005. <www.sciencedaily.com/releases/2005/09/050930080433.htm>.
University of California - Davis. (2005, September 30). New Lifespan Extension Genes Found. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2005/09/050930080433.htm
University of California - Davis. "New Lifespan Extension Genes Found." ScienceDaily. www.sciencedaily.com/releases/2005/09/050930080433.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins