Featured Research

from universities, journals, and other organizations

Genetic Mutation Linked To West Nile Virus Infection

Date:
January 26, 2006
Source:
Journal of Experimental Medicine
Summary:
A genetic mutation that protects against HIV increases the risk of developing clinical West Nile virus infection, according to a new study appearing online on January 9th in the Journal of Experimental Medicine.

A genetic mutation that protects against HIV increases the risk of developing clinical West Nile Virus infection, according to a new study appearing online on January 9th in The Journal of Experimental Medicine.

Related Articles


The mutation in question is a small deletion in a gene that encodes a protein called CCR5, which was identified in 1996 as a co-receptor used by HIV to infect cells. Individuals with two copies of this mutation (CCR5delta32) are highly resistant to HIV infection, even when repeatedly exposed to the virus.

This resistance was the theoretical basis for the development of therapeutic CCR5 inhibitors, several of which are now in clinical trials, for the treatment of patients with HIV. CCR5 seemed like an ideal drug target, as people missing the receptor were healthy and no diseases or infections had been shown to be more frequent or severe in individuals carrying the CCR5delta32 mutation.

But new evidence suggests that the lack of CCR5 is not completely innocuous. Philip Murphy and his colleagues at the National Institute of Allergy and Infectious Diseases (Bethesda, MD) recently showed that infection with WNV -- a mosquito-borne virus that caused a1999 outbreak of fatal encephalitis in the US -- was uniformly fatal in mice that lack CCR5.

This finding prompted Murphy and his colleagues to look for the CCR5delta32 mutation in patients in the US who were diagnosed with WNV infections. They now report that individuals with two copies of CCR5delta32 were more frequent among WNV patients than in the general population, suggesting that the lack of CCR5 puts people at risk for developing clinical WNV infections. In mice, the lack of CCR5 prevents protective immune cells from gaining access to the brain where they can fight off the infection. It remains to be seen whether the same mechanism is at play in humans.

This study might raise a red flag for the use of CCR5 inhibitors in HIV-infected patients -- at least in areas endemic for WNV -- as such inhibitors might increase the recipients' vulnerability to severe WNV infection.


Story Source:

The above story is based on materials provided by Journal of Experimental Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Experimental Medicine. "Genetic Mutation Linked To West Nile Virus Infection." ScienceDaily. ScienceDaily, 26 January 2006. <www.sciencedaily.com/releases/2006/01/060126142055.htm>.
Journal of Experimental Medicine. (2006, January 26). Genetic Mutation Linked To West Nile Virus Infection. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2006/01/060126142055.htm
Journal of Experimental Medicine. "Genetic Mutation Linked To West Nile Virus Infection." ScienceDaily. www.sciencedaily.com/releases/2006/01/060126142055.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins