Featured Research

from universities, journals, and other organizations

New Study Reveals Promising Osteoporosis Treatment

Date:
March 13, 2006
Source:
New York University
Summary:
A New York University College of Dentistry professor has developed a calcium phosphate-based supplement that -- even at low concentrations -- significantly improves bone strength and thickness without the side effects of many current drug treatments.

A New York University College of Dentistry professor has developed a calcium phosphate-based supplement that -- even at low concentrations -- significantly improves bone strength and thickness without the side effects of many current drug treatments. Dr. Racquel Z. LeGeros, a Professor of Biomaterials and Biomimetics and of Implant Dentistry, presented her research on the supplement at the American Association for Dental Research annual meeting on March 9, 2006.

Related Articles


Current FDA-approved pharmaceutical-based osteoporosis treatments, such as bisphosphonate drugs and hormone therapies, do not effectively repair bone that has already been lost. In fact, bisphosphonates have been shown to actually inhibit bone redevelopment. Many of these treatments also have serious side effects, including increasing the risk of heart disease, strokes, and breast cancer.

But the supplement Dr. LeGeros developed by combining magnesium (Mg), zinc (Zn), and fluoride (F) ions in a calcium-phosphate (CaP) matrix does not have the side effects of the current pharmaceutical-based treatments. Perhaps more importantly, a Mg/Zn/F-CaP supplement would be inexpensive to produce and would not require FDA approval. Dr. LeGeros' formulation could be available to market as an over-the-counter supplement, pending patent approval.

In her study, Dr. LeGeros investigated the effect in rats of Mg/Zn/F-CaP ion combinations on several bone properties: strength, thickness, quality, and composition of bones.

Dr. LeGeros divided a sample of 72 (36 males, 36 females) adult Sprague-Dawley rats (average weight, 160g) into six groups receiving the following diets: control; mineral deficiency-induced osteoporosis (MD); MD supplemented with Mg-CaP; Zn-CaP; F-CaP; and Mg/Zn/F-CaP. Each supplement was 0.6% of the MD diet. The post-mortem examination of the femurs in the MD Mg/Zn/F-CaP group showed that even this small amount of Mg/Zn/F-CaP supplement substantially improved bone strength and thickness. More studies will be needed, ultimately using human trials to confirm the results.

Dr. LeGeros' paper, Effect of Mg/Zn/F-CaP Supplements on Bone Properties: Phase 1, describes initial results of her research, which is funded by a four-year, $2 million grant from the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health.

Osteoporosis is a silent, progressive, and debilitating disease characterized by bone loss and the thinning of cortical bone leading to bone fracture. In the United States, the disease affects an estimated 10 million older adults, resulting in more than 1.5 million fractures annually; the overwhelming majority of those afflicted with osteoporosis (80%) are women.

Dr. LeGeros said future research may also focus on using Mg/Zn/F-CaP compounds to repair fractures and periodontal bone defects.



Story Source:

The above story is based on materials provided by New York University. Note: Materials may be edited for content and length.


Cite This Page:

New York University. "New Study Reveals Promising Osteoporosis Treatment." ScienceDaily. ScienceDaily, 13 March 2006. <www.sciencedaily.com/releases/2006/03/060312213934.htm>.
New York University. (2006, March 13). New Study Reveals Promising Osteoporosis Treatment. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2006/03/060312213934.htm
New York University. "New Study Reveals Promising Osteoporosis Treatment." ScienceDaily. www.sciencedaily.com/releases/2006/03/060312213934.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins