Featured Research

from universities, journals, and other organizations

Charred Meat Chemical May Lead To Prostate Cancer

Date:
April 6, 2006
Source:
Johns Hopkins Kimmel Cancer Center
Summary:
The compound PhIP -- formed by cooking meats at very high temperatures -- acts as both an initiator and promoter of prostate cancer in rats, according to a Johns Hopkins Kimmel Cancer Center study, presented at the 97th annual meeting of the American Association for Cancer Research in Washington, D.C.

The compound PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine), formed by cooking meats at very high temperatures, acts as both an initiator and promoter of prostate cancer in rats, according to a Johns Hopkins Kimmel Cancer Center study, presented at the 97th annual meeting of the American Association for Cancer Research in Washington, D.C.

Previous research in rats has shown that PhIP causes early prostate cancer lesions only in the front of the organ called the ventral lobe, and not in other lobes. To begin to unravel why these pre-cancers congregate in this area, Yatsutomo Nakai, lead author on the study, mixed PhIP into food given to a group of rats for up to eight weeks, then studied the animals’ prostates, intestines and spleens to look for genetic mutations. After four weeks, all lobes had significantly elevated mutations compared to rats that did not ingest PhIP. After eight weeks, researchers observed a significant increase in proliferation only in the ventral lobe, indicating that PhIP caused additional “promotional” events only in that lobe.

Researchers also observed in that lobe alone an increase in inflammatory mast cells and macrophages, suggesting that these cells may contribute to the development of prostate cancer.

“We stumbled across a new potential interaction between ingestion of cooked meat in the diet and cancer in the rat,” says coauthor Angelo De Marzo, M.D., senior author of the study and an associate professor of pathology, urology and oncology. “For humans, the biggest problem is that it’s extremely difficult to tell how much PhIP you’ve ingested, since different amounts are formed depending on cooking conditions.”

Coauthors were Jessica L. Hicks and William G. Nelson.


Story Source:

The above story is based on materials provided by Johns Hopkins Kimmel Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Kimmel Cancer Center. "Charred Meat Chemical May Lead To Prostate Cancer." ScienceDaily. ScienceDaily, 6 April 2006. <www.sciencedaily.com/releases/2006/04/060406101252.htm>.
Johns Hopkins Kimmel Cancer Center. (2006, April 6). Charred Meat Chemical May Lead To Prostate Cancer. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2006/04/060406101252.htm
Johns Hopkins Kimmel Cancer Center. "Charred Meat Chemical May Lead To Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2006/04/060406101252.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mini Pacemaker Has No Wires

Mini Pacemaker Has No Wires

Ivanhoe (Aug. 27, 2014) Cardiac experts are testing a new experimental device designed to eliminate major surgery and still keep the heart on track. Video provided by Ivanhoe
Powered by NewsLook.com
After Cancer: Rebuilding Breasts With Fat

After Cancer: Rebuilding Breasts With Fat

Ivanhoe (Aug. 27, 2014) More than 269 million women are diagnosed with breast cancer each year. Many of them will need surgery and radiation, but there’s a new simple way to reconstruct tissue using a patient’s own fat. Video provided by Ivanhoe
Powered by NewsLook.com
Blood Clots in Kids

Blood Clots in Kids

Ivanhoe (Aug. 27, 2014) Every year, up to 200,000 Americans die from a blood clot that travels to their lungs. You’ve heard about clots in adults, but new research shows kids can get them too. Video provided by Ivanhoe
Powered by NewsLook.com
Radio Waves Knock out Knee Pain

Radio Waves Knock out Knee Pain

Ivanhoe (Aug. 27, 2014) Doctors have used radio frequency ablation or RFA to reduce neck and back pain for years. But now, that same technique is providing longer-term relief for patients with severe knee pain. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins