Featured Research

from universities, journals, and other organizations

Facial Resurfacing Treats Precancerous Skin Lesions, May Help Prevent Skin Cancer

Date:
August 25, 2006
Source:
JAMA and Archives Journals
Summary:
Facial skin resurfacing with lasers, an acid skin peel or a topical cream may reduce the number of precancerous skin lesions and lower the risk of developing skin cancer, according to a report in the August issue of the Archives of Dermatology, one of the JAMA/Archives journals.

Facial skin resurfacing with lasers, an acid skin peel or a topical cream may reduce the number of precancerous skin lesions and lower the risk of developing skin cancer, according to a report in the August issue of the Archives of Dermatology, one of the JAMA/Archives journals.

Approximately 3.7 million physician visits occur in the United States every year for actinic keratoses, skin lesions that are sensitive to the effects of ultraviolet light. About 331 per 100,000 such lesions per year will progress into the skin cancer squamous cell carcinoma in patients older than age 40 years, according to background information in the article. As many as one-fourth of patients with multiple actinic keratoses will develop squamous cell carcinoma, and up to 60 percent of such cancers are thought to originate from actinic keratoses. Current treatment generally involves freezing the lesions with liquid nitrogen. "However, despite an overreliance by dermatologists on liquid nitrogen, there are, to our knowledge, no published studies that justify this expensive treatment modality as an efficient means to reduce the financial impact of actinic keratoses and nonmelanoma skin cancer on the health care system," the authors write.

Basil M. Hantash, M.D., Ph.D., and colleagues at Veterans Affairs Palo Alto Health Care System and Stanford University Medical Center, California, evaluated three alternative treatments for actinic keratoses in 24 patients with a history of lesions or of carcinoma. The participants had an average age of 73 years and were randomly assigned to undergo skin resurfacing with either a carbon dioxide laser, a chemical peel using 30 percent trichloroacetic acid or a cream with 5 percent fluorouracil, a medication used in chemotherapy, applied twice daily for three weeks. Dermatologists charted patients' actinic keratoses on a diagram of the head at the beginning of the study and again every three months for a period of at least 24 months. Five patients who were eligible for the study but declined treatment were used as controls.

After three months, the number of actinic keratoses had decreased significantly in all three treatment groups: 83 percent in the fluorouracil group, 89 percent in the acid group and 92 percent in the laser group. None of the participants experience adverse effects from treatment. The risk of cancer was also lower in all three treatment groups than in the control group; patients in the acid group, in particular, had a 40-fold lower rate of nonmelanoma skin cancer than those in the control group. Patients in that group also reported fewer complaints, less discomfort and a faster healing time than those in the other two treatment groups.

"Improved patient compliance in the trichloroacetic acid arm, ease of performance in the outpatient setting and subjective measures of better tolerance for this procedure make it an attractive alternative to repeated courses with topical agents or laser resurfacing," the authors conclude. "A larger study comparing trichloroacetic acid resurfacing for actinic keratosis reduction and nonmelanoma skin cancer prophylaxis [prevention] would help validate the superiority of this resurfacing technique over the carbon dioxide laser and assess its cost-effectiveness" compared with other therapies.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Facial Resurfacing Treats Precancerous Skin Lesions, May Help Prevent Skin Cancer." ScienceDaily. ScienceDaily, 25 August 2006. <www.sciencedaily.com/releases/2006/08/060825103630.htm>.
JAMA and Archives Journals. (2006, August 25). Facial Resurfacing Treats Precancerous Skin Lesions, May Help Prevent Skin Cancer. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2006/08/060825103630.htm
JAMA and Archives Journals. "Facial Resurfacing Treats Precancerous Skin Lesions, May Help Prevent Skin Cancer." ScienceDaily. www.sciencedaily.com/releases/2006/08/060825103630.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins