Featured Research

from universities, journals, and other organizations

Liver Diagnosis Breakthrough With Mayo Clinic MRI Development

Date:
September 8, 2006
Source:
Mayo Clinic
Summary:
Mayo Clinic researchers have developed a new technique for using magnetic resonance imaging to accurately measure the hardness or elasticity of the liver. First tests show this technology -- called MR Elastography -- holds great promise for detecting liver fibrosis, a common condition that can lead to incurable cirrhosis if not treated in time.

Mayo Clinic researchers have developed a new technique for using magnetic resonance imaging (MRI) to accurately measure the hardness or elasticity of the liver. First tests show this technology -- called MR Elastography (MRE) -- holds great promise for detecting liver fibrosis, a common condition that can lead to incurable cirrhosis if not treated in time.

Related Articles


Traditionally, liver fibrosis is usually diagnosed using needle biopsies, which can involve complications and may be inaccurate due to sampling errors. The new technology promises to provide an accurate, painless, and lower risk alternative to liver biopsy and may have implications for diagnosing cancer. These research findings appeared in the journal Radiology.

"This is potentially an important diagnostic advance, since conventional imaging techniques, such as CT, MRI and ultrasound are not capable of identifying liver fibrosis prior to the onset of cirrhosis," says Richard Ehman, M.D. (opens in new window), Mayo researcher and lead investigator on the study.

"The Elastogram"

The healthy liver is very soft compared to most other tissues and especially compared to a liver with cirrhosis, which is rock hard. The development by Dr. Ehman and his colleagues applies vibrations to the liver and then utilizes a modified form of MRI to obtain pictures of the mechanical waves passing through the organ. The imaging can be accomplished in as little as 20 seconds. The wave pictures are then processed to generate a quantitative image of tissue stiffness -- called an elastogram.

Researchers compared results of the process on 12 patients with biopsy-proven liver fibrosis with those of 12 healthy participants. This pilot trial of MRE showed strikingly elevated stiffness in patients with fibrosis and that the stiffness increased with the progression of the condition.

Impact of the Research

The availability of a reliable, non-invasive method for detecting liver fibrosis could lead to early diagnosis -- in patients considered at risk for liver disease -- and increase their chances for successful treatment. For example, 170 million people worldwide are infected with chronic hepatitis C and a significant number will develop cirrhosis, which is untreatable. Even if some risk factors are identified, there is no way to predict which patients will develop fibrosis, and successive liver biopsies in all these patients aren't possible. Non-invasive monitoring with MRE of those at risk would detect the problem early and help assess the effect of treatments.

Collaboration and Support

Others on the research team include Meng Yin; Olivier Rouviere, M.D.; Jayant Talwalkar, M.D.; M. Alex Dresner, Ph.D.; Phillip Rossman; Lawrence Burgart, M.D.; and Jeff Fidler, M.D. The research was funded in part by the National Institutes of Health.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Liver Diagnosis Breakthrough With Mayo Clinic MRI Development." ScienceDaily. ScienceDaily, 8 September 2006. <www.sciencedaily.com/releases/2006/09/060908094153.htm>.
Mayo Clinic. (2006, September 8). Liver Diagnosis Breakthrough With Mayo Clinic MRI Development. ScienceDaily. Retrieved January 29, 2015 from www.sciencedaily.com/releases/2006/09/060908094153.htm
Mayo Clinic. "Liver Diagnosis Breakthrough With Mayo Clinic MRI Development." ScienceDaily. www.sciencedaily.com/releases/2006/09/060908094153.htm (accessed January 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, January 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

AFP (Jan. 29, 2015) Oxfam International has called for a multi-million dollar post-Ebola "Marshall Plan", with financial support given by wealthy countries, to help Guinea, Sierra Leone and Liberia to recover. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Are We Winning The Fight Against Ebola?

Are We Winning The Fight Against Ebola?

Newsy (Jan. 29, 2015) The World Health Organization announced the fight against Ebola has entered its second phase as the number of cases per week has steadily dropped. Video provided by Newsy
Powered by NewsLook.com
Measles Scare Sends 66 Calif. Students Home

Measles Scare Sends 66 Calif. Students Home

AP (Jan. 29, 2015) Officials say 66 students at a Southern California high school have been told to stay home through the end of next week because they may have been exposed to measles and are not vaccinated. (Jan. 29) Video provided by AP
Powered by NewsLook.com
Group Encourages Black Moms to Breastfeed

Group Encourages Black Moms to Breastfeed

AP (Jan. 29, 2015) A grassroots effort is underway in several US cities to encourage more black women to breastfeed their babies by teaching them the benefits of the age-old practice, which is sometimes shunned in African-American communities. (Jan. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins