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Development Of New Polymer Delivery Vehicles For Gene Therapy

Date:
October 17, 2006
Source:
American Chemical Society
Summary:
MIT scientists are reporting synthesis and laboratory tests of a promising new group of degradable polymer delivery vehicles for gene therapy. The polymers are improved versions of materials first described in 2000 that deliver genes efficiently to specific cells.

MIT scientists are reporting synthesis and laboratory tests of a promising new group of degradable polymer delivery vehicles for gene therapy. The polymers are improved versions of materials first described in 2000 that deliver genes efficiently to specific cells.

The lack of a safe, efficient delivery system for DNA has been a major barrier to clinical use of gene therapy. Viruses and various polymer materials have been used in efforts to insert therapeutic genes into diseased cells. However, those systems have disadvantages. Some of the polymer materials, for instance, insert genes into only a small percentage of cells and do not degrade in the body.

Robert Langer and colleagues used laboratory experiments to show that the polymers can deliver DNA to human liver cancer cells. Their report is scheduled for the current (Oct. 15) issue of the weekly Journal of the American Chemical Society.

One polymer has potential for carrying genes to the supply of tiny blood vessels that enables cancer cells to grow and spread. "We are currently testing the targeting effects of this polymer on endothelial cells, and it is envisioned that this delivery system could permit localization and transfection of the tumor vasculature for cancer therapies," the report states.


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The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


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American Chemical Society. "Development Of New Polymer Delivery Vehicles For Gene Therapy." ScienceDaily. ScienceDaily, 17 October 2006. <www.sciencedaily.com/releases/2006/10/061016121908.htm>.
American Chemical Society. (2006, October 17). Development Of New Polymer Delivery Vehicles For Gene Therapy. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2006/10/061016121908.htm
American Chemical Society. "Development Of New Polymer Delivery Vehicles For Gene Therapy." ScienceDaily. www.sciencedaily.com/releases/2006/10/061016121908.htm (accessed April 17, 2014).

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