Featured Research

from universities, journals, and other organizations

White Blood Cells Of Cancer-resistant Mice Overwhelm Natural Defenses Of Cancer Cells

Date:
November 1, 2006
Source:
Wake Forest University Baptist Medical Center
Summary:
The discoverers of the unique mouse line that is resistant to cancer have begun to pin down how the process works and found that white blood cells in these mice overwhelm normal defenses of cancer cells.

The discoverers of the unique mouse line that is resistant to cancer have begun to pin down how the process works and found that white blood cells in these mice overwhelm normal defenses of cancer cells.

Related Articles


In a report in Cancer Immunity, a journal of the Academy of Cancer Immunology, posted on line today, Zheng Cui, M.D., Ph.D., and Mark C. Willingham, M.D., of Wake Forest University School of Medicine and colleagues said that several types of white blood cells in the mice attack cancer cells by sensing, finding and surrounding them, forming a "rosette," and then killing them.

"Apparently, the mutation in the cancer-resistant mice renders the white blood cells capable of sensing unique diffusible and surface signals from cancer cells and responding to those signals by migration and physical contact," they said.

The researchers said that in ordinary mice, the white blood cells are suppressed by self-defensive signals coming from the cancer cells and don't attack the cancer. But the mutated gene or genes in the cancer-resistant mouse changes the white blood cells so they interpret those same signals from the cancer cells as an invitation to attack.

"Identifying the mutated gene (or genes) will likely explain this unique resistance to cancer through immunity," said Cui, associate professor of pathology.

Earlier this year, the same team reported in the Proceedings of the National Academy of Sciences that white blood cells taken from these cancer-resistant mice cured advanced cancers in ordinary mice and also protected those normal mice from what should have been lethal doses of highly aggressive new cancers.

But while pursuing the ability of these white blood cells to cure cancer in ordinary mice, and beginning to explore whether the same process could work in humans, the researchers have also continued to investigate how the original mutation works, a mutation that protects the cancer-resistant mice from a wide variety of injected cancer cells.

Cui and Willingham said the killing of the cancer cells in the cancer-resistant mouse requires three distinct steps:

  • First, the white blood cells migrate to the site of cancer cells after sensing their presence.
  • Second, they recognize unique properties on the surface of the cancer cells and closely surround those cells.
  • Third, a lethal dose of each white-blood-cell type's cancer-killing compound is delivered to the cancer cells. The killing molecule varies with the white-cell type.

The ordinary mice lack the first two steps.

The researchers found that the anti-tumor response involved white blood cells of the so-called innate immune system, which the body ordinarily employs to fight off bacteria, but which had not been thought to be effective in fighting off cancer. Instead, in these cancer-resistant mice, three white-blood-cell types of the innate immune system -- neutrophils, macrophages and natural killer cells -- all infiltrate the tumor site in a multi-pronged killing response.

"Each cell type had independent killing activity against the cancer cells," the authors said, using different molecules. Macrophages, for instance, have to be in physical contact with the cancer cell before unleashing its combination of killer molecules.

White blood cells from the cancer-resistant mice apparently have the same ability to attack a range of tumors when transplanted to ordinary mice.

Cui and Willingham also want to explore how this one process can detect a wide range of cancer cells of so many different types. The dogma of cancer fighters has always postulated that there are many different cancers. "This new research in mice suggests that there may be some things that most cancers have in common," said Willingham, a pathologist and head of the Section on Tumor Biology.

Support for the research came from the Cancer Research Institute and the National Cancer Institute. Coauthors include Amy M. Hicks, Ph.D., Wei Du, M.D., Changlee S. Pang, M.D., all of Wake Forest, and Lloyd J. Old, M.D., of the Ludwig Institute for Cancer Research.


Story Source:

The above story is based on materials provided by Wake Forest University Baptist Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Wake Forest University Baptist Medical Center. "White Blood Cells Of Cancer-resistant Mice Overwhelm Natural Defenses Of Cancer Cells." ScienceDaily. ScienceDaily, 1 November 2006. <www.sciencedaily.com/releases/2006/10/061031185404.htm>.
Wake Forest University Baptist Medical Center. (2006, November 1). White Blood Cells Of Cancer-resistant Mice Overwhelm Natural Defenses Of Cancer Cells. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2006/10/061031185404.htm
Wake Forest University Baptist Medical Center. "White Blood Cells Of Cancer-resistant Mice Overwhelm Natural Defenses Of Cancer Cells." ScienceDaily. www.sciencedaily.com/releases/2006/10/061031185404.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins