Featured Research

from universities, journals, and other organizations

Berry Compound Thwarts Enzyme Linked To Cancer

Date:
January 3, 2007
Source:
USDA/Agricultural Research Service
Summary:
Recent research by Agricultural Research Service (ARS) scientists and cooperators has fortified the standing of pterostilbene, a berry and grape compound cited for its health benefits, as a cancer inhibitor. During tests employing cell fragments from mice livers, ARS chemist Agnes Rimando and colleagues in Poland found that the compound strongly suppresses a type of an enzyme that activates cancer-causing processes.

Using gas chromatography/mass spectrometry, chemist Agnes Rimando analyzes pterostilbene content in blueberries.
Credit: Photo by Peggy Greb

Recent research by Agricultural Research Service (ARS) scientists and cooperators has fortified the standing of pterostilbene, a berry and grape compound cited for its health benefits, as a cancer inhibitor.

During tests employing cell fragments from mice livers, ARS chemist Agnes Rimando and colleagues in Poland found that the compound strongly suppresses a type of an enzyme that activates cancer-causing processes.

Rimando, who works at the ARS Natural Products Utilization Research Laboratory in Oxford, Miss., and her collaborators targeted an enzyme called cytochrome P450, which sets off a variety of compounds--known as "procarcinogens--that can turn substances such as cigarette smoke and pesticides into cancer-causing agents. Cytochromes are a factor in people's varying responses to drugs and toxins entering their bodies.

Rimando has led numerous animal studies that focused on pterostilbene (pronounced "tare-o-STILL-bean") and its potential benefits to human health. This includes work showing that pterostilbene can help lower cholesterol and prevent heart disease, and that the compound is present in a genus of shrubs that includes many types of berries, including blueberries.

She also led studies that found that the compound is a powerful antioxidant that shows cancer-fighting properties similar to those of resveratrol. Indeed, pterostilbene is a derivative of resveratrol, a compound found in large quantities in the skins of red grapes that's known for its cardiovascular and cancer-fighting benefits.

In the most recent study, Rimando and scientists led by Renata Mikstacka at Poland's University of Medical Science in Poznaρ tested pterostilbene and other resveratrol derivatives.

Pterostilbene showed strong inhibitory activity--much more than resveratrol--against a particular form of cytochrome P450, according to Rimando. She added that the results may explain the cancer-preventive property the compound demonstrated in a mouse mammary gland culture assay.

However, Rimando cautioned that more studies are needed to explain this process, as well as the activity of other trans-resveratrol compounds.

ARS is the U.S. Department of Agriculture's chief scientific research agency.


Story Source:

The above story is based on materials provided by USDA/Agricultural Research Service. Note: Materials may be edited for content and length.


Cite This Page:

USDA/Agricultural Research Service. "Berry Compound Thwarts Enzyme Linked To Cancer." ScienceDaily. ScienceDaily, 3 January 2007. <www.sciencedaily.com/releases/2007/01/070102140955.htm>.
USDA/Agricultural Research Service. (2007, January 3). Berry Compound Thwarts Enzyme Linked To Cancer. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2007/01/070102140955.htm
USDA/Agricultural Research Service. "Berry Compound Thwarts Enzyme Linked To Cancer." ScienceDaily. www.sciencedaily.com/releases/2007/01/070102140955.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) — The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) — Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) — A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) — The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins