Featured Research

from universities, journals, and other organizations

Modified Bone Marrow Cells Help Treat Multiple Sclerosis In Animal Model

Date:
April 16, 2007
Source:
Public Library of Science
Summary:
A new study has shown that modified bone marrow cells can help recovery in an animal model of multiple sclerosis (MS).

TREM2-transduced myeloid precursors (green) facilitating tissue debris clearance in an inflammatory spinal cord lesion of experimental autoimmune encephalomyelitis.
Credit: Image courtesy of Public Library of Science

A new study has shown that modified bone marrow cells can help recovery in an animal model of multiple sclerosis (MS). Harald Neumann and colleagues from the University of Bonn modified myeloid precursor cells to express a protein (triggering receptor expressed on myeloid cells-2 (TREM2), which is normally made by microglia - a cell from the nervous system - and injected these TREM2-expressing cells into the veins of mice with experimental autoimmune encephalomyelitis (EAE, an animal model of MS).

The researchers examined the migration of these cells into the spinal cord of the mice, their effect on the symptoms of EAE, and what effect there was on the clearance of cell debris and inflammatory responses in the spinal cord of the mice. They found that neither TREM2-expressing nor control myeloid precursor cells migrated into the spinal cord when injected into healthy mice or into animals just beginning to show the symptoms of EAE.

However, both control and modified cells migrated into the spinal cord when injected into animals when EAE symptoms were at their peak. The injection of TREM2-expressing myeloid precursor cells (but not control myeloid precursor cells) at this time reduced EAE symptoms and nerve damage, and halted loss of myelin and also increased the clearance of cell debris and myelin fragments.

These findings will need to be repeated in further animal models before the implications for human disease are clear; however, they open up an avenue of further research.

Citation: Takahashi K, Prinz M, Stagi M, Chechneva O, Neumann H (2007) TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. PLoS Med 4(4): e124. (http://dx.doi.org/10.1371/journal.pmed.0040124)


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Modified Bone Marrow Cells Help Treat Multiple Sclerosis In Animal Model." ScienceDaily. ScienceDaily, 16 April 2007. <www.sciencedaily.com/releases/2007/04/070410084124.htm>.
Public Library of Science. (2007, April 16). Modified Bone Marrow Cells Help Treat Multiple Sclerosis In Animal Model. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2007/04/070410084124.htm
Public Library of Science. "Modified Bone Marrow Cells Help Treat Multiple Sclerosis In Animal Model." ScienceDaily. www.sciencedaily.com/releases/2007/04/070410084124.htm (accessed October 20, 2014).

Share This



More Plants & Animals News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Rare Lion Cubs Make Debut at Belgrade Zoo

Raw: Rare Lion Cubs Make Debut at Belgrade Zoo

AP (Oct. 17, 2014) Two white lion cubs were born in Belgrade zoo three weeks ago. White lions are a rare mutation of a species found in South Africa and some cultures consider them divine. (Oct. 17) Video provided by AP
Powered by NewsLook.com
The Best Foods To Boost Your Mood

The Best Foods To Boost Your Mood

Buzz60 (Oct. 17, 2014) Feeling down? Reach for the refrigerator, not the medicine cabinet! TC Newman (@PurpleTCNewman) shares some of the best foods to boost your mood. Video provided by Buzz60
Powered by NewsLook.com
Sweet Times for Hard Cider Makers

Sweet Times for Hard Cider Makers

AP (Oct. 16, 2014) With hard cider making a hardcore comeback across the country, craft makers are trying to keep up with demand and apple growers are tapping a juicy new revenue stream. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Meet Garfi the Angry Cat

Meet Garfi the Angry Cat

Buzz60 (Oct. 16, 2014) Garfi is one frowny, feisty feline - downright angry! Ko Im (@koimtv) introduces us to the latest animal celebrity taking over the Internet. You can follow more of Garfi's adventures on Twitter (@MeetGarfi) and Facebook (Garfi). Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins