Featured Research

from universities, journals, and other organizations

Susceptibility To Crohn's Disease -- An Important New Clue

Date:
April 21, 2007
Source:
Public Library of Science
Summary:
Crohn's disease is a chronic relapsing inflammatory disorder of the intestinal tract that affects an estimated 0.15 percent of people in the developed world. In a genome-wide association study with more than 300,000 single nucleotide polymorphisms -- DNA sequence variations occurring when a single nucleotide in the genome differs between members of a species -- Cécile Libioulle et al. identified a new susceptibility locus for Crohn's disease.

Crohn's disease is a chronic relapsing inflammatory disorder of the intestinal tract that affects an estimated 0.15% of people in the developed world. Common symptoms include abdominal pain and diarrhea, but the disorder is often associated with debilitating clinical complications. Researchers from the University of Liège, Belgium, have now uncovered an important clue to the susceptibility of individuals to this disease.

In a genome-wide association study with more than 300,000 single nucleotide polymorphisms (SNPs) -- DNA sequence variations occurring when a single nucleotide in the genome differs between members of a species -- Cécile Libioulle et al. identified a new susceptibility locus for Crohn's disease. Their results are published online in the open-access journal PLoS Genetics.

Recent advances in SNP genotyping technology have allowed systematic association scanning of the entire genome for the detection of novel susceptibility loci -- fixed positions on a chromosome, such as the position of a gene. Libioulle and colleagues applied this approach to Crohn's disease and identified the key locus on chromosome 5.

Individual susceptibility to many common diseases, including Crohn's disease, is determined by a combination of environmental and genetic factors and identifying these genetic risk factors is one of the most important objectives of modern medical genetics, potentially paving the way towards personalized medicine and drug target identification.

CITATION: Libioulle C, Louis E, Hansoul S, Sandor C, Farnir F, et al. (2007) Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet 3(4): e58. doi:10.1371/journal.pgen.0030058


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Susceptibility To Crohn's Disease -- An Important New Clue." ScienceDaily. ScienceDaily, 21 April 2007. <www.sciencedaily.com/releases/2007/04/070420104748.htm>.
Public Library of Science. (2007, April 21). Susceptibility To Crohn's Disease -- An Important New Clue. ScienceDaily. Retrieved August 2, 2014 from www.sciencedaily.com/releases/2007/04/070420104748.htm
Public Library of Science. "Susceptibility To Crohn's Disease -- An Important New Clue." ScienceDaily. www.sciencedaily.com/releases/2007/04/070420104748.htm (accessed August 2, 2014).

Share This




More Health & Medicine News

Saturday, August 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) — After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) — A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) — Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) — Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins