May 7, 2007 Researchers have found that a diet rich in fish, seafood, and grains -- also called polyunsaturated fats -- is better at preventing heart disease than a diet containing olive oil, nuts, and avocados -- called monounsaturated fats. Although both types of fats are healthy, people should probably include more of the first than the second in their diet to keep a healthy heart, the scientists say.
Too much cholesterol has long been linked to increasing risks of developing heart disease, but it has been less clear how the various dietary fats -- saturated, monounsaturated and polyunsaturated -- make people susceptible to the disease.
Lawrence L. Rudel and colleagues developed a method to determine the effects of the three types of dietary fats on acyl-coenzyme A, a key molecule involved in the metabolism of fatty acids. The scientists found that mice fed diets high in saturated and monounsaturated fat showed an increase in acyl-coenzyme A compared to mice fed a diet enriched in polyunsaturated fat. These results suggest that polyunsaturated fat is a more suitable replacement than monounsaturated fat for dietary saturated fat, the scientists concluded.
Article: "Monounsaturated fatty acyl-CoA is predictive of atherosclerosis in human ApoB100 transgenic, LDLr-/- mice" by Thomas A. Bell III, Martha D. Wilson, Kathryn Kelley, Janet K. Sawyer, and Lawrence L. Rudel
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