Featured Research

from universities, journals, and other organizations

Scientists Make Significant Advance In Understanding Gastroenteritis-causing Noroviruses

Date:
June 28, 2007
Source:
University of Southampton
Summary:
A breakthrough announced this week by scientists at the University of Southampton's School of Medicine will lead to greater understanding of noroviruses, the most common cause of non-bacterial gastroenteritis around the world.

Human noroviruses, which are closely related to the murine norovirus, are responsible for extensive outbreaks of diarrhoea and vomiting in cruise ships, hotels, schools and hospitals.
Credit: Image courtesy of University of Southampton

A breakthrough announced this week by scientists at the University of Southampton's School of Medicine will lead to greater understanding of noroviruses, the most common cause of non-bacterial gastroenteritis around the world.

Traditionally very little has been known about the biology of noroviruses because of the difficulty in culturing and manipulating these pathogens in the laboratory. Now the Southampton team, assisted by colleagues at the University of Otago and Washington University Medical School, has devised a system for manipulating the genome of the murine norovirus (MNV) which affects rodents. This breakthrough will lead to a greater understanding of how these pathogens work and, it is hoped, lead to ways of controlling them.

Human noroviruses, which are closely related to the murine norovirus, are responsible for extensive outbreaks of diarrhoea and vomiting in cruise ships, hotels, schools and hospitals. Up to a million cases of norovirus infection are estimated to occur annually in the UK.

'The human noroviruses have been exceedingly difficult to work with as there is no cell culture system to propagate these viruses, and as a result very little is known about their biology,' comments Professor Ian Clarke, who heads the Virus Group at Southampton.

'In the absence of a cell culture system, MNV is a surrogate for study of the human noroviruses. This study represents the culmination of a ten-year research quest in Southampton to obtain recovery of a live norovirus from its nucleic acid.'

The team in Southampton included Drs Vernon Ward, Christopher McCormick, Omar Salim and Paul Lambden and Professor Clarke. Together with Drs Larissa Thackray, Christiane Wobus and Skip Virgin at Washington University School of Medicine they devised a novel way of introducing a complete DNA copy of the MNV RNA genome into human cells grown in the laboratory. This allowed recovery for the first time of intact, functional viral particles from human tissue culture. They also used their system to mutate the virus so that they could identify a sequence that is essential for viral replication.

Their reverse infectious genetics system will be an essential tool for understanding the replication and molecular biology of this and human noroviruses and will help in the development of antivirals aimed at controlling infections.

The work, which was funded through a Wellcome Trust project grant, is published in the Proceedings of the National Academy of Sciences (USA) this week.


Story Source:

The above story is based on materials provided by University of Southampton. Note: Materials may be edited for content and length.


Cite This Page:

University of Southampton. "Scientists Make Significant Advance In Understanding Gastroenteritis-causing Noroviruses." ScienceDaily. ScienceDaily, 28 June 2007. <www.sciencedaily.com/releases/2007/06/070627225110.htm>.
University of Southampton. (2007, June 28). Scientists Make Significant Advance In Understanding Gastroenteritis-causing Noroviruses. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2007/06/070627225110.htm
University of Southampton. "Scientists Make Significant Advance In Understanding Gastroenteritis-causing Noroviruses." ScienceDaily. www.sciencedaily.com/releases/2007/06/070627225110.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
American Ebola Patient Apparently Improving, Outbreak Is Not

American Ebola Patient Apparently Improving, Outbreak Is Not

Newsy (Aug. 19, 2014) Nancy Writebol, an American missionary who contracted Ebola, is apparently getting better, according to her husband. The outbreak, however, is not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins