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Regulating Embryonic Stem Cell Self-renewal

Date:
October 22, 2007
Source:
Cold Spring Harbor Laboratory
Summary:
Scientists have identified two genes -- called Jmjd1a and Jmjd2c -- that regulate self-renewal in embryonic stem cells. This finding will have important ramifications for embryonic stem cell research.

Dr. Huck-Hui Ng and colleagues at the Genome Institute of Singapore have identified two genes -- called Jmjd1a and Jmjd2c -- that regulate self-renewal in embryonic stem cells. This finding will have important ramifications for embryonic stem cell research.

"These are new pathways that the ES cell uses to counteract inappropriate silencing of key pluripotency genes. Perturbation of these pathways affects the maintenance of ES cells," explains Dr. Ng.

Embryonic stem cells (ES cells) are pluripotent: They can differentiate into any of the specialized cell types of the body (excluding the placenta), as well as new, undifferentiated (unspecialized) stem cells (a process known as "self-renewal"). Understanding the genetic basis of self-renewal is integral to the long-term maintenance of viable ES cell lines.

Dr. Ng and colleagues investigated how modifications to chromatin structure influence gene transcription and ES cell function. The researchers found that Jmjd1a and Jmjd2c, which encode enzymes that demethylate histone H3 lysine 9, regulate self-renewal in mouse ES cells: Depletion of Jmjd1a and Jmjd2c promoted differentiation, at the expense of self-renewal. Thus, these two histone modifying enzymes are required for maintaining pluripotency of ES cells.

This research is published In the October 15th issue of Genes & Development.


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The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


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Cold Spring Harbor Laboratory. "Regulating Embryonic Stem Cell Self-renewal." ScienceDaily. ScienceDaily, 22 October 2007. <www.sciencedaily.com/releases/2007/10/071018171454.htm>.
Cold Spring Harbor Laboratory. (2007, October 22). Regulating Embryonic Stem Cell Self-renewal. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2007/10/071018171454.htm
Cold Spring Harbor Laboratory. "Regulating Embryonic Stem Cell Self-renewal." ScienceDaily. www.sciencedaily.com/releases/2007/10/071018171454.htm (accessed October 1, 2014).

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