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Amphibian Skin Agent May Battle Multi-drug Resistant Bacteria

Date:
January 23, 2008
Source:
American Society for Microbiology
Summary:
Researchers found that a naturally occurring agent in frog skin may inhibit multi-drug resistant bacterial strains associated with hospital-acquired infections. Resistance to current antibiotic therapies is on the rise in both hospital and community settings. With some bacterial strains now resistant to every available drug, a return to the preantibiotic era in regard to such infections is cause for great concern.

Common Frog, Rana temporaria.
Credit: Image courtesy of Wikimedia Commons

Researchers from Italy found that a naturally occurring agent in frog skin may inhibit multi-drug resistant bacterial strains associated with hospital-acquired infections.

Resistance to current antibiotic therapies is on the rise in both hospital and community settings. With some bacterial strains now resistant to every available drug, a return to the preantibiotic era in regard to such infections is cause for great concern. Researchers have identified antimicrobial peptides (AMPs) as one of the most promising candidates for future therapeutic use and they have found amphibian skin to be one of the richest sources of such AMPs.

Nosocomial infections are linked to various drug-resistant bacterial strains and are commonly acquired in a hospital setting as a secondary illness. In the study researchers tested five AMPs (temporins A, B, and G, esculentin 1b, and bombinin H2) from three different frog and toad species (Rana temporaria, Rana esculenta, and Bombina variegata) for antibacterial activity against multi-drug resistant strains often associated with human nosocomial infections. Initial results showed that all the peptides acted as antibacterial agents against the species tested. Further studies found that the temporins were more active against gram-positive bacteria; esculentin 1b produced an antibacterial response within 2 to 20 minutes of exposure, and bombinin H2 displayed similar activity toward all bacterial isolates.

“This peptide is an attractive molecule for use in the development of new compounds for the treatment of infectious diseases,” say the researchers.

Reference: M.L. Mangoni, G. Maisetta, M.D. Luca, L.M.H. Gaddi, S. Esin, W. Florio, F.L. Brancatisano, D. Barra, M. Campa, G. Batoni. 2008. Comparative analysis of the bactericidal activities of amphibian peptide analogues against multi-drug-resistant nosocomial bacterial strains. Antimicrobial Agents and Chemotherapy, 52. 1: 85-91.


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The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Microbiology. "Amphibian Skin Agent May Battle Multi-drug Resistant Bacteria." ScienceDaily. ScienceDaily, 23 January 2008. <www.sciencedaily.com/releases/2008/01/080122102502.htm>.
American Society for Microbiology. (2008, January 23). Amphibian Skin Agent May Battle Multi-drug Resistant Bacteria. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2008/01/080122102502.htm
American Society for Microbiology. "Amphibian Skin Agent May Battle Multi-drug Resistant Bacteria." ScienceDaily. www.sciencedaily.com/releases/2008/01/080122102502.htm (accessed October 1, 2014).

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