Featured Research

from universities, journals, and other organizations

Timing Is Everything When Using IL-7 To Boost Antiviral Immunity

Date:
February 3, 2008
Source:
Journal of Clinical Investigation
Summary:
CD8+ T cells are an important component of the antiviral immune response. Much research effort is being invested in identifying new ways to boost antiviral immune responses in individuals with chronic viral infections. Although the use of the soluble factor IL-7 has proven attractive, new data indicate that the timing of IL-7 treatment is important in determining how effective it is at enhancing antiviral immunity.

CD8+ T cells are an important component of antiviral immune responses.

Related Articles


Much research effort is being invested in identifying new ways to boost antiviral immune responses in individuals with chronic viral infections (such as those infected with HIV and hepatitis C virus) and to boost the efficacy of vaccines designed to target these viruses.

The use of the soluble factor IL-7, which is known to be important in the generation and maintenance of memory CD8+ T cells, has proven attractive. However, new data, generated in mice by M. Suresh and colleagues at the University of Wisconsin--Madison, have indicated that the timing of IL-7 treatment is important in determining how effective it is at enhancing antiviral immunity.

In the study, IL-7 was shown to enhance the number and function of memory CD8+ T cells only if it was administered during the contraction phase of the immune response mounted after mice were infected with either lymphocytic choriomeningitis virus or vaccinia virus, or were administered a DNA vaccine.

Importantly, CD8+ T cells from IL-7--treated mice exhibited improved viral control. These data have clinical implications for the use of IL-7 as an immunotherapeutic agent both to bolster vaccine-induced CD8+ T cell memory and to boost the immune response of individuals with a chronic viral infection.

The article "Effects of IL-7 on memory CD8+ T cell homeostasis are influenced by the timing of therapy in mice" was published in the Journal of Clinical Investigation February 1, 2008.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Timing Is Everything When Using IL-7 To Boost Antiviral Immunity." ScienceDaily. ScienceDaily, 3 February 2008. <www.sciencedaily.com/releases/2008/02/080203101434.htm>.
Journal of Clinical Investigation. (2008, February 3). Timing Is Everything When Using IL-7 To Boost Antiviral Immunity. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2008/02/080203101434.htm
Journal of Clinical Investigation. "Timing Is Everything When Using IL-7 To Boost Antiviral Immunity." ScienceDaily. www.sciencedaily.com/releases/2008/02/080203101434.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins