Featured Research

from universities, journals, and other organizations

Bone Complications Due To Cystic Fibrosis Have A Genetic Cause, According To Study

Date:
February 13, 2008
Source:
McGill University Health Centre
Summary:
A recent study sheds some new light on the bone problems that generally accompany cystic fibrosis. The new study is pointing at genetics as contributing to this bone frailty, a finding which may have some implications in changing therapeutic practices.

A recent study by Dr Christina Haston, a researcher of the McGill University Health Centre research Institute, sheds some new light on the bone problems that generally accompany cystic fibrosis. Dr Haston's study is pointing at genetics as contributing to this bone frailty, a finding which may have some implications in changing therapeutic practices.

The medical community generally considers the bone fragility associated with cystic fibrosis to be multifactorial. It is thought to be a consequence of the mutation of the Cftr gene, the gene responsible for cystic fibrosis, of the pancreatic disease associated with cystic fibrosis and of the treatment with steroids to facilitate breathing.

The study showed that mice with a Cftr gene mutation have a bone mineral density and bone mass that are significantly lower than those of control mice. This difference occurs without the pancreatic insufficiency seen clinically and in the absence of steroid treatment.

This conclusion clearly defines cystic-fibrosis-related bone problems as an additional pathology stemming from the Cftr mutation and not as a side effect of treatment. This may have some therapeutic consequences as it opens an avenue for defining a targeted treatment in mice.

Although the precise mechanism that links this mutation to bone development is unknown, studying these mice at different ages corresponding to childhood, adolescence and adulthood has shown that the bone structures of mice with the Cftr mutation get closer to the norm as the mice age; in other words, the genetic mutation seems to just slow bone growth and not prevent it. However, this partial conclusion requires further study to be confirmed.

Dr Christina Haston is cross-appointed as researcher in the Meakins-Christie Laboratories of the McGill University Health Centre research Institute, and she is also an assistant professor in the Faculty of Medicine of McGill University.

The research article was published on February 1, 2008 in the American Journal of Respiratory and Critical Care Medicine. This study was funded by the Canadian Cystic Fibrosis Foundation, the Canadian Institutes for Health Research, Valorisation Recherche Quebec, and the Fonds de la Recherche en Santι du Quιbec.


Story Source:

The above story is based on materials provided by McGill University Health Centre. Note: Materials may be edited for content and length.


Cite This Page:

McGill University Health Centre. "Bone Complications Due To Cystic Fibrosis Have A Genetic Cause, According To Study." ScienceDaily. ScienceDaily, 13 February 2008. <www.sciencedaily.com/releases/2008/02/080207115358.htm>.
McGill University Health Centre. (2008, February 13). Bone Complications Due To Cystic Fibrosis Have A Genetic Cause, According To Study. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2008/02/080207115358.htm
McGill University Health Centre. "Bone Complications Due To Cystic Fibrosis Have A Genetic Cause, According To Study." ScienceDaily. www.sciencedaily.com/releases/2008/02/080207115358.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) — A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) — Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) — The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) — A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins