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Bone Complications Due To Cystic Fibrosis Have A Genetic Cause, According To Study

Date:
February 13, 2008
Source:
McGill University Health Centre
Summary:
A recent study sheds some new light on the bone problems that generally accompany cystic fibrosis. The new study is pointing at genetics as contributing to this bone frailty, a finding which may have some implications in changing therapeutic practices.

A recent study by Dr Christina Haston, a researcher of the McGill University Health Centre research Institute, sheds some new light on the bone problems that generally accompany cystic fibrosis. Dr Haston's study is pointing at genetics as contributing to this bone frailty, a finding which may have some implications in changing therapeutic practices.

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The medical community generally considers the bone fragility associated with cystic fibrosis to be multifactorial. It is thought to be a consequence of the mutation of the Cftr gene, the gene responsible for cystic fibrosis, of the pancreatic disease associated with cystic fibrosis and of the treatment with steroids to facilitate breathing.

The study showed that mice with a Cftr gene mutation have a bone mineral density and bone mass that are significantly lower than those of control mice. This difference occurs without the pancreatic insufficiency seen clinically and in the absence of steroid treatment.

This conclusion clearly defines cystic-fibrosis-related bone problems as an additional pathology stemming from the Cftr mutation and not as a side effect of treatment. This may have some therapeutic consequences as it opens an avenue for defining a targeted treatment in mice.

Although the precise mechanism that links this mutation to bone development is unknown, studying these mice at different ages corresponding to childhood, adolescence and adulthood has shown that the bone structures of mice with the Cftr mutation get closer to the norm as the mice age; in other words, the genetic mutation seems to just slow bone growth and not prevent it. However, this partial conclusion requires further study to be confirmed.

Dr Christina Haston is cross-appointed as researcher in the Meakins-Christie Laboratories of the McGill University Health Centre research Institute, and she is also an assistant professor in the Faculty of Medicine of McGill University.

The research article was published on February 1, 2008 in the American Journal of Respiratory and Critical Care Medicine. This study was funded by the Canadian Cystic Fibrosis Foundation, the Canadian Institutes for Health Research, Valorisation Recherche Quebec, and the Fonds de la Recherche en Santι du Quιbec.


Story Source:

The above story is based on materials provided by McGill University Health Centre. Note: Materials may be edited for content and length.


Cite This Page:

McGill University Health Centre. "Bone Complications Due To Cystic Fibrosis Have A Genetic Cause, According To Study." ScienceDaily. ScienceDaily, 13 February 2008. <www.sciencedaily.com/releases/2008/02/080207115358.htm>.
McGill University Health Centre. (2008, February 13). Bone Complications Due To Cystic Fibrosis Have A Genetic Cause, According To Study. ScienceDaily. Retrieved January 25, 2015 from www.sciencedaily.com/releases/2008/02/080207115358.htm
McGill University Health Centre. "Bone Complications Due To Cystic Fibrosis Have A Genetic Cause, According To Study." ScienceDaily. www.sciencedaily.com/releases/2008/02/080207115358.htm (accessed January 25, 2015).

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