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Glycine Could Be Key To REM Sleep Behavior Disorder, Study Shows

Date:
March 28, 2008
Source:
University of Toronto
Summary:
New research holds promise for thousands who suffer from REM Sleep Behavior Disorder. RDB, a neurological disorder that causes violent twitches and muscle contractions during rapid eye-movement (REM) sleep, can lead to serious injuries.

There is new promise on the horizon for those who suffer from REM Sleep Behaviour Disorder (RBD) according to researchers at the University of Toronto.

RDB, a neurological disorder that causes violent twitches and muscle contractions during rapid eye-movement (REM) sleep, can lead to serious injuries. John Peever, Assistant Professor at the University of Toronto, discovered that an inhibitory brain chemical called glycine is responsible for actively suppressing muscle twitches in REM sleep.

Deficiency in glycine levels in the brain cells that control muscles (motoneurons) was found to cause the violent muscle contractions that mimic the primary symptom of RBD.

"This study shows the mechanism that suppresses muscles twitches in REM sleep and this will lead to better treatments and potential cures for this disorder," says Peever. "Treating REM sleep disorder may have much broader implications, since within five to eight years of being diagnosed with this disorder, 60-80% of individuals eventually develop Parkinson's disease."

The study findings are published in the March 26th edition of the Journal of Neuroscience.


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The above story is based on materials provided by University of Toronto. Note: Materials may be edited for content and length.


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University of Toronto. "Glycine Could Be Key To REM Sleep Behavior Disorder, Study Shows." ScienceDaily. ScienceDaily, 28 March 2008. <www.sciencedaily.com/releases/2008/03/080327172155.htm>.
University of Toronto. (2008, March 28). Glycine Could Be Key To REM Sleep Behavior Disorder, Study Shows. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2008/03/080327172155.htm
University of Toronto. "Glycine Could Be Key To REM Sleep Behavior Disorder, Study Shows." ScienceDaily. www.sciencedaily.com/releases/2008/03/080327172155.htm (accessed July 25, 2014).

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