Featured Research

from universities, journals, and other organizations

How Arsenic Can Cure One Type Of Leukemia

Date:
April 19, 2008
Source:
CNRS
Summary:
Arsenic is a remarkably effective treatment against a rare form of leukemia. Researchers have shown how arsenic cures one type of leukemia. This research should lead to a better understanding of the therapy, and thus to medical strategies which are better adapted to this disease.

Arsenic is a remarkably effective treatment against a rare form of leukemia. Researchers from a CNRS / Université Paris Diderot research unit, based at the Institut Universitaire d'Hématologie at Hôpital Saint Louis, have shown how arsenic cures this type of leukemia. This research should lead to a better understanding of the therapy, and thus to medical strategies which are better adapted to this disease.

Related Articles


Arsenic is a poison which has been used in medicine for more than 3000 years.  It is now regularly used to treat acute promyelocytic leukemia. This type of leukemia is characterized by the fusion of PML and RARA proteins, which is sufficient to make cells leukemic. Earlier, Pr. Hugues de Thé’s team had shown that arsenic induces the SUMOylation of PML/RARA, SUMO being a peptide that regulates interaction between proteins.  But the nature of the degradation pathway remained a mystery, because SUMO generally works against degradation.

A new enzyme which participates in this mechanism, RNF4, has recently been identified by the researchers. This enzyme plays a key role in the recognition and degradation of PML/RARA forms which have been modified by arsenic (PML/RARA-SUMO). The work of the French team, like that of an English team publishing in the same journal, shows that RNF4 binds to PML-SUMO or PML/RARA-SUMO. It then fixes another peptide, ubiquitin, onto this complex.  Ubiquitin is known to lead to the degradation of proteins to which is binds.  Ubiquitin then modifies the PML/RARA-SUMO protein.

The existence of a degradation pathway, initiated by SUMO and completed by ubiquitin, had been predicted by genetic studies on yeast, but no susbtrate had been identified. This research should lead to a better understanding of the molecular bases for therapy, and to better strategies for treating this illness.

Journal reference : Arsenic degrades PML or PML-RARA through a SUMO-triggered RNF4/ubiquitin-mediated pathway, Lallemand-Breitenbach, V., Jeanne, M., Benhenda, S., Nasr, R., Lei, M., Peres, L., Zhou, J., Zhu, J., Raught, B., and de The, H., Nature Cell Biology, 13 April 2008 (online)


Story Source:

The above story is based on materials provided by CNRS. Note: Materials may be edited for content and length.


Cite This Page:

CNRS. "How Arsenic Can Cure One Type Of Leukemia." ScienceDaily. ScienceDaily, 19 April 2008. <www.sciencedaily.com/releases/2008/04/080416220013.htm>.
CNRS. (2008, April 19). How Arsenic Can Cure One Type Of Leukemia. ScienceDaily. Retrieved March 3, 2015 from www.sciencedaily.com/releases/2008/04/080416220013.htm
CNRS. "How Arsenic Can Cure One Type Of Leukemia." ScienceDaily. www.sciencedaily.com/releases/2008/04/080416220013.htm (accessed March 3, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 3, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) — Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) — If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) — GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) — How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins