Featured Research

from universities, journals, and other organizations

Scientists 'Paint' Viruses To Track Their Fate In The Body

Date:
May 21, 2008
Source:
Federation of American Societies for Experimental Biology
Summary:
Here's a new twist on the relationship between biology and art. Researchers describe how they were able to coat--or paint--viruses with proteins. This breakthrough should boost the efficiency of some forms of gene therapy, help track and treat viral disease and evolution, improve the efficiency of vaccines, and ultimately allow health-care professionals track the movement of viral infections within the body.

Biologists from Austria and Singapore developed a technique that adds a new twist on the relationship between biology and art. Researchers describe how they were able to coat--or paint--viruses with proteins. This breakthrough should give a much-needed boost to the efficiency of some forms of gene therapy, help track and treat viral disease and evolution, improve the efficiency of vaccines, and ultimately allow health care professionals track the movement of viral infections within the body. Specifically, the new method should make it easier to track and treat infectious diseases such as HIV/AIDS, influenza, hepatitis C, and dengue fever.

And because viruses can also be used to introduce biotechnology drugs and replacement genes, and act as vaccines, this research should lead to new treatments for cancer, cardiovascular, metabolic and inherited disorders.

"This technology should provide a new tool for the treatment of many diseases," said Brian Salmons, one of scientists who co-authored the study. "Even if you are working with a virus that is unknown or poorly characterized, it is still possible to modify or paint it. This is very interesting for emerging diseases."

In the article in the FASEB journal, Salmons and colleagues explain how they mixed purified proteins (glycosylphophatidylinositol anchor proteins) with lipid membranes to make it possible to bind these proteins to the outer "skin" (the lipid envelope) of viruses. Even with the new paint job, the viruses remained infectious. While the experiment only involved one type of protein and two types of viral vectors, Salmons says the technique could be expanded and used to apply "paint" made up of other proteins, dyes, and a variety of unique markers.

"Biology and art converge daily: people paint their nails, color their hair, and tattoo their skin," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Now this convergence has entered a new dimension as painted viruses permit scientists to track, cure and prevent disease."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Association of glycosylphosphatidylinositol-anchored protein with retroviral particles. Christoph Metzner, Meike M Mostegl, Walter H. Günzburg, Brian Salmons, and John A. Dangerfield. FASEB. Published online before print May 13, 2008 as doi: 10.1096/fj.08-108217. [link]

Cite This Page:

Federation of American Societies for Experimental Biology. "Scientists 'Paint' Viruses To Track Their Fate In The Body." ScienceDaily. ScienceDaily, 21 May 2008. <www.sciencedaily.com/releases/2008/05/080520103432.htm>.
Federation of American Societies for Experimental Biology. (2008, May 21). Scientists 'Paint' Viruses To Track Their Fate In The Body. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2008/05/080520103432.htm
Federation of American Societies for Experimental Biology. "Scientists 'Paint' Viruses To Track Their Fate In The Body." ScienceDaily. www.sciencedaily.com/releases/2008/05/080520103432.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) — The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) — Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) — A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) — The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins