A team led by Professor You-Ming Li from Zhejiang University has investigated the association of alcohol dose, duration of drinking and obesity with liver injury in the island population east of China. The risk threshold of daily alcohol intake and duration of drinking inducing alcohol-related liver injury was 20 grams and five years in the island population.
Obesity induced liver injury should also be considered.
Alcoholic threshold effect rather than a dose-response effect on mortality from alcohol-related liver injury. Alcohol intake, rather than the type of alcoholic beverage, was more significant to liver injury.
In the view of the authors, to date no clear explanation has existed to evaluate alcohol-related liver injury in China's island population.
The island population east of China is a specific cluster population. Their alcohol consumption is very high compared to that of the mainland population. However, there is a lack of population-based alcoholic liver disease (ALD) studies on China's islands.
The authors conducted a population-based case-control study to investigate the association of alcohol dose, duration of drinking and obesity with liver injury in the island population east of China.
The results will be useful in further analyzing the differences between the island population and the inland population, in terms of drinking habits, diet habits, life and work pressure and genotype. The island population should be further studied in follow-up research.
- Shen Z, Li YM, Yu CH, Shen Y, Xu L, Xu CF, Chen JJ, Ye H, Xu GY. Risk factors for alcohol-related liver injury in the island population from China: A Population-based Case-control study. World J Gastroenterol 2008; 14(14): 2255-2261 doi: 10.3748/wjg.14.2255 [link]
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