Featured Research

from universities, journals, and other organizations

Challenges Of HIV-1 Subtype Diversity

Date:
May 21, 2008
Source:
Henry M. Jackson Foundation for the Advancement of Military Medicine
Summary:
The genetic variation of HIV-1 and its implications for preventing and treating the disease have recently been explored. HIV-1 is classified into several subtypes, or clades, which are denoted by letters. Subtype B is most prevalent in the Americas, whereas clades A, C and D are most prevalent in Sub-Saharan Africa, the region that remains most severely affected by the pandemic.

A review article in the New England Journal of Medicine explores the genetic variation of HIV-1 and its implications for preventing and treating the disease. Francine McCutchan, Ph.D., a researcher with the U.S. Military HIV Research Program, co-authored the article, which appeared in the April 10, 2008 edition.

Related Articles


HIV-1 is classified into several subtypes, or clades, which are denoted by letters. Subtype B is most prevalent in the Americas, whereas clades A, C and D are most prevalent in Sub-Saharan Africa, the region that remains most severely affected by the pandemic.

Advances in full-genome sequencing, along with expanded disease surveillance, have enabled researchers to identify circulating and recombinant forms of the disease as well.

"Given the diversity of HIV-1, gathering and classifying its strains has been very challenging. Nevertheless, this data provides the foundation for understanding the virus, its spread and how to combat it," said Dr. McCutchan.

The authors address the implications viral diversity has on HIV prevention, vaccine development and antiretroviral therapy. For example, subtypes and their interaction with the human host may influence disease progression and transmission. They cite a cohort study in the Rakai district in Uganda, which suggested that HIV-1 disease progression is more rapid, and the risk of death is greater, among persons infected with subtype D (with recombinant forms or multiple subtypes) than those infected with subtype A.


Story Source:

The above story is based on materials provided by Henry M. Jackson Foundation for the Advancement of Military Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Henry M. Jackson Foundation for the Advancement of Military Medicine. "Challenges Of HIV-1 Subtype Diversity." ScienceDaily. ScienceDaily, 21 May 2008. <www.sciencedaily.com/releases/2008/05/080521133456.htm>.
Henry M. Jackson Foundation for the Advancement of Military Medicine. (2008, May 21). Challenges Of HIV-1 Subtype Diversity. ScienceDaily. Retrieved January 28, 2015 from www.sciencedaily.com/releases/2008/05/080521133456.htm
Henry M. Jackson Foundation for the Advancement of Military Medicine. "Challenges Of HIV-1 Subtype Diversity." ScienceDaily. www.sciencedaily.com/releases/2008/05/080521133456.htm (accessed January 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, January 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Malnutrition on the Rise as Violence Flares in C. Africa

Malnutrition on the Rise as Violence Flares in C. Africa

AFP (Jan. 28, 2015) Violence can flare up at any moment in Bambari with only a bridge separating Muslims and Christians. Malnutrition is on the rise and lack of water means simple cooking fires threaten to destroy makeshift camps where people are living. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Media Criticizing Parents For Not Vaccinating Children

Media Criticizing Parents For Not Vaccinating Children

Newsy (Jan. 28, 2015) As the Disneyland measles outbreak continues to spread, the media says parents who choose not to vaccinate their children are part of the cause. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins