Featured Research

from universities, journals, and other organizations

Genetic Variation Affects Brain Region Dysfunctional In Schizophrenia

Date:
May 22, 2008
Source:
Journal of Clinical Investigation
Summary:
New data have indicated that in healthy individuals, variation in a gene known as AKT1 affects the structure and function of part of the brain that is dysfunctional in individuals with schizophrenia. This genetic variation was also found to be associated with an increased risk for schizophrenia, something that has important therapeutic implications.

New data, generated by Daniel Weinberger and colleagues, at the National Institutes of Health, Bethesda, have indicated that in healthy individuals, variation in a gene known as AKT1 affects the structure and function of part of the brain that is dysfunctional in individuals with schizophrenia.

Related Articles


Specifically, in healthy individuals, one particular AKT1 variant was associated with impaired cognition (an impaired ability to process information), something that is markedly affected in individuals with schizophrenia.

In addition, the same AKT1 variant was associated with decreased grey-matter volume in the frontostriatal region of the brain, which is dysfunctional in individuals with schizophrenia.

Further analysis indicated that the AKT1 variant was associated with an increased risk of schizophrenia and the therapeutic implications of this, as well as the other results of the study, are discussed in an accompanying commentary by Alexander Arguello and Joseph Gogos, at Columbia University College of Physicians and Surgeons, New York.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans. Journal of Clinical Investigation. May 22, 2008. doi:10.1172/JCI34725

Cite This Page:

Journal of Clinical Investigation. "Genetic Variation Affects Brain Region Dysfunctional In Schizophrenia." ScienceDaily. ScienceDaily, 22 May 2008. <www.sciencedaily.com/releases/2008/05/080522181529.htm>.
Journal of Clinical Investigation. (2008, May 22). Genetic Variation Affects Brain Region Dysfunctional In Schizophrenia. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2008/05/080522181529.htm
Journal of Clinical Investigation. "Genetic Variation Affects Brain Region Dysfunctional In Schizophrenia." ScienceDaily. www.sciencedaily.com/releases/2008/05/080522181529.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Former NFL Players Donate Brains to Science

Former NFL Players Donate Brains to Science

Reuters - US Online Video (Mar. 3, 2015) Super Bowl champions Sidney Rice and Steve Weatherford donate their brains, post-mortem, to scientific research into repetitive brain trauma. Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Alzheimer's Protein Plaque Found In 20-Year-Olds

Alzheimer's Protein Plaque Found In 20-Year-Olds

Newsy (Mar. 3, 2015) Researchers found an abnormal protein associated with Alzheimer&apos;s disease in the brains of 20-year-olds. Video provided by Newsy
Powered by NewsLook.com
This Nasal Treatment Could Help Ease Migraine Pain

This Nasal Treatment Could Help Ease Migraine Pain

Newsy (Mar. 2, 2015) Researchers gave lidocaine to 112 patients, and about 88 percent of the subjects said they needed less migraine-relief medicine the next day. Video provided by Newsy
Powered by NewsLook.com
How Facebook Use Can Lead To Depression

How Facebook Use Can Lead To Depression

Newsy (Mar. 1, 2015) Margaret Duffy of the University of Missouri talks about her study on the social network and the envy and depression that Facebook use can cause. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins