Featured Research

from universities, journals, and other organizations

Building A Better DNA Molecule

Date:
May 27, 2008
Source:
Weizmann Institute of Science
Summary:
Scientists have demonstrated that a mathematical concept called recursion can be applied to constructing flawless synthetic DNA molecules. The ideal molecules are created in successive rounds in which faultless segments are lifted from longer, error-containing DNA strands and assembled anew.

Building faultless objects from faulty components may seem like alchemy. Yet scientists from the Weizmann Institute’s Computer Science and Applied Mathematics, and Biological Chemistry Departments have achieved just that, using a mathematical concept called recursion. 'We all use recursion, intuitively, to compose and comprehend sentences like ‘the dog that chases the cat that bit the mouse that ate the cheese that the man dropped is black,’' says Prof. Ehud Shapiro.

Recursion allows long DNA molecules to be composed hierarchically from smaller building blocks. But synthetic DNA building blocks have random errors within their sequence, as do the resulting molecules. Correcting these errors is necessary for the molecules to be useful. Even though the synthetic molecules are error prone, some of them are likely to have long stretches that do not contain any faults.

These stretches of faultless DNA can be identified, extracted, and reused in another round of recursive construction. Starting from longer and more accurate building blocks in this round increases the chances of producing a flawless long DNA molecule. The team, led by doctoral students Gregory Linshiz and Tuval Ben-Yehezkel under the supervision of Shapiro, found in their experiments that two rounds of recursive construction were enough to produce a flawless target DNA molecule. If need be, however, the error correction procedure could be repeated until the desired molecule is formed.

The team’s research, recently published in the journal Molecular Systems Biology, provides a novel way to construct faultless DNA molecules with greater speed, precision, and ease of combining synthetic and natural DNA fragments than existing methods. 'Synthetic DNA molecules are widely needed in bio-logical and biomedical research, and we hope that their efficient and accurate construction using this recursive process will help to speed up progress in these fields,' says Shapiro.

Prof. Ehud Shapiro’s research is supported by the Clore Center for Biological Physics; the Arie and Ida Crown Memorial Charitable Fund; the Cymerman - Jakubskind Prize; the Fusfeld Research Fund; the Phyllis and Joseph Gurwin Fund for Scientific Advancement; the Henry Gutwirth Fund for Research; Ms. Sally Leafman Appelbaum, Scottsdale, AZ; the Carolito Stiftung, Switzerland; the Louis Chor Memorial Trust Fund; and the estate of Fannie Sherr, New York, NY. Prof. Shapiro is the incumbent of the Harry Weinrebe Chair of Computer Science and Biology.


Story Source:

The above story is based on materials provided by Weizmann Institute of Science. Note: Materials may be edited for content and length.


Cite This Page:

Weizmann Institute of Science. "Building A Better DNA Molecule." ScienceDaily. ScienceDaily, 27 May 2008. <www.sciencedaily.com/releases/2008/05/080527094154.htm>.
Weizmann Institute of Science. (2008, May 27). Building A Better DNA Molecule. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2008/05/080527094154.htm
Weizmann Institute of Science. "Building A Better DNA Molecule." ScienceDaily. www.sciencedaily.com/releases/2008/05/080527094154.htm (accessed April 24, 2014).

Share This



More Plants & Animals News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
Raw: Kangaroo Rescued from Swimming Pool

Raw: Kangaroo Rescued from Swimming Pool

AP (Apr. 24, 2014) A kangaroo was saved from drowning in a backyard suburban swimming pool in Australia's Victoria state on Thursday. Australian broadcaster Channel 7 showed footage of the kangaroo struggling to get out of the pool. (April 24) Video provided by AP
Powered by NewsLook.com
Could Marijuana Use Lead To Serious Heart Problems?

Could Marijuana Use Lead To Serious Heart Problems?

Newsy (Apr. 24, 2014) A new study says marijuana use could lead to serious heart-related complications. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins