Featured Research

from universities, journals, and other organizations

Enzyme May Hold Key To Improved Targeting Of Cancer-fighting Drugs

Date:
June 1, 2008
Source:
Boston College
Summary:
Building on their earlier research into neocarzinostatin, a team of researchers discovered that one of the enzymes contained in the bacteria used to produce the drug may hold promise in creating newer, more stable compounds from the structurally complex class of antibiotic known as chromoproteins.

A critical enzyme used to prepare a powerful cancer-killing agent may be able to help drug makers better target the cells the natural product attacks, according to findings published in the May 23 edition of the Journal of Biological Chemistry.

Building on their earlier research into neocarzinostatin, a team of researchers from Boston College and the University of Wisconsin, Madison discovered that one of the enzymes contained in the bacteria used to produce the drug may hold promise in creating newer, more stable compounds from the structurally complex class of antibiotic known as chromoproteins.

"We've revealed that the enzyme is loose in specificity, which means it may be able to be used to make new drugs," said Boston College Chemist Steven D. Bruner, a co-author of the report. "Based on these findings, we foresee success in the lab making certain compounds more controllable."

In addition to Bruner, the research team includes BC graduate student Heather A. Cooke and University of Wisconsin Professor Ben Shen and researchers Yinggang Luo, Shuangjun Lin and Jian Zhang.

Used as a chemotherapeutic, the drug -- an enediyne anti-tumor agent -- targets both normal and cancer cells, says Bruner, an assistant professor of chemistry. But the team has determined that the chemical components of the antibiotic are capable of distinguishing between normal cells and cancer cells.

The latest research confirmed the team's proposal that the naphthoic acid within the compound can be altered to design cancer-fighting drugs specific to chemotherapeutic targets. That will require the use of genetic engineering in order to manipulate the molecules within the bacteria, which occurs naturally in soil.

Genetic engineering will enable researchers to produce more specific and less toxic analogs of neocarzinostatin and increase the available supply of the drug, Bruner says.

"This is the beginning of an approach to be able to understand and manipulate these chemical pathways to make new drugs," says Bruner.


Story Source:

The above story is based on materials provided by Boston College. Note: Materials may be edited for content and length.


Cite This Page:

Boston College. "Enzyme May Hold Key To Improved Targeting Of Cancer-fighting Drugs." ScienceDaily. ScienceDaily, 1 June 2008. <www.sciencedaily.com/releases/2008/05/080529162558.htm>.
Boston College. (2008, June 1). Enzyme May Hold Key To Improved Targeting Of Cancer-fighting Drugs. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2008/05/080529162558.htm
Boston College. "Enzyme May Hold Key To Improved Targeting Of Cancer-fighting Drugs." ScienceDaily. www.sciencedaily.com/releases/2008/05/080529162558.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins