Featured Research

from universities, journals, and other organizations

Fat Mass And Obesity-associated Genes Increase Risk Of Disease In Mexican-Americans

Date:
June 15, 2008
Source:
University of Southern California
Summary:
A new study suggests people of Mexican-American descent who have genetic variants of fat gene FTO and Arachidonate 5-Lipoxygenase (5-LO) had higher triglyceride and lower HDL levels.

A study from the University of Southern California (USC) suggests people of Mexican-American descent who have genetic variants of fat gene FTO and Arachidonate 5-Lipoxygenase (5-LO) had higher triglyceride and lower HDL levels.

"Our results confirm the association between FTO and fat mass and indicate that the 5-LO promoter modifies the association between FTO and lipid levels," says Mary Helen Black, candidate for PhD in Statistical Genetics and Genetic Epidemiology, at the Keck School of Medicine of USC and lead author of the study. "The genetic interaction between 5-LO and FTO was significantly associated with an inverse relationship between triglycerides and HDL levels."

The study examined 1286 participants from 165 Mexican American family members of a proband with a history of gestational diabetes and 107 control trios from the BetaGene study. Results suggest subjects who have the FTO rs9939609 A allele and at least one 5-LO short repeat allele had a 26 percent higher triglyceride count and 8 percent lower HDL cholesterol levels compared to participants with the FTO TT genotype. In contrast, among participants with two 5-LO long repeat alleles, those with an FTO A allele showed very little change in triglycerides or HDL compared to those with the FTO TT genotype.

"Understanding the interaction between these genes may help us understand the mechanism by which FTO affects adiposity. Because obesity and dyslipidemia are often precursors to diabetes, these gene interactions may play a vital role in future drug target development, which is another step toward advancing personalized medicine," Black says.

The findings were presented as an oral presentation on Sunday, June 8, at the American Diabetes Association 68th Scientific Sessions held in San Francisco. Authors of the study "Arachidonate 5-Lipoxygenase (5-LO) Modifies the Association Between Fat Mass- and Obesity-Associated Gene (FTO) and Lipids in Mexican Americans (MA),"  include Mary Helen Black, Jaana Hartiala, Anny H. Xiang, Enrique Trigo, Jean M. Lawrence, Thomas A. Buchanan, Richard M. Watanabe, Hooman Allayee.  


Story Source:

The above story is based on materials provided by University of Southern California. Note: Materials may be edited for content and length.


Cite This Page:

University of Southern California. "Fat Mass And Obesity-associated Genes Increase Risk Of Disease In Mexican-Americans." ScienceDaily. ScienceDaily, 15 June 2008. <www.sciencedaily.com/releases/2008/06/080610092738.htm>.
University of Southern California. (2008, June 15). Fat Mass And Obesity-associated Genes Increase Risk Of Disease In Mexican-Americans. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2008/06/080610092738.htm
University of Southern California. "Fat Mass And Obesity-associated Genes Increase Risk Of Disease In Mexican-Americans." ScienceDaily. www.sciencedaily.com/releases/2008/06/080610092738.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Predicting Heart Transplant Rejection With a Blood Test

Predicting Heart Transplant Rejection With a Blood Test

Ivanhoe (Aug. 27, 2014) — Now a new approach to rejection of donor organs could change the way doctors predict transplant rejection…without expensive, invasive procedures. Video provided by Ivanhoe
Powered by NewsLook.com
Better Braces That Vibrate

Better Braces That Vibrate

Ivanhoe (Aug. 27, 2014) — The length of time you have to keep your braces on could be cut in half thanks to a new device that speeds up the process. Video provided by Ivanhoe
Powered by NewsLook.com
Smartphone App Tracks Your Heart Rate

Smartphone App Tracks Your Heart Rate

Ivanhoe (Aug. 27, 2014) — A new app that can track your heart rate 24/7 is available for download in your app store and its convenience could save your life. Video provided by Ivanhoe
Powered by NewsLook.com
Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) — A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins