Featured Research

from universities, journals, and other organizations

Multiple Regions Of Chromosome 8 Found To Be Associated With Different Cancers

Date:
June 26, 2008
Source:
Journal of the National Cancer Institute
Summary:
A recently discovered, but not yet understood, section of chromosome 8, called 8q24, may contain at least five distinct regions that are associated with different cancers, according to a study in the June 24 issue of the Journal of the National Cancer Institute.

A recently discovered, but not yet understood, section of chromosome 8, called 8q24, may contain at least five distinct regions that are associated with different cancers, according to a study in the June 24 issue of the Journal of the National Cancer Institute.

Recent genome-wide studies suggested that genetic alterations in the 8q24 region are associated with a risk of prostate, colorectal and breast cancer. The region does not contain any known genes and is referred to as a gene desert, but researchers have mapped it using single nucleotide polymorphisms (SNPs) as markers.

To determine whether 8q24 acts as a single region associated with all of these cancers or if it could be sub-divided into smaller regions, Maya Ghoussaini, Ph.D., of the University of Cambridge and colleagues tested the associations of nine SNPs spaced along the region in four different sets of DNA, each comprising patients with one of the four cancers and healthy controls.

The authors' analysis suggests that there may be five distinct subregions within 8q24, separated by sites of frequent recombination, and each associated with different types of cancer. The first subregion is associated with an increased risk of prostate cancer but not with risk of breast, colorectal, or ovarian cancer. The second is associated only with an increased risk of breast cancer. The third subregion is associated with the risk of prostate, colorectal and ovarian cancers, but not breast, and subregions four and five were associated with prostate cancer, but not with the other three malignancies.

"We have shown there are at least five independent loci within this gene desert with different associations with particular cancers," the authors write. "Further studies of the region may identify additional loci associated with specific cancers and possibly refine our understanding of the mechanisms underlying the associations reported here."


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ghoussaini et al. Multiple Loci With Different Cancer Specificities Within the 8q24 Gene Desert. JNCI Journal of the National Cancer Institute, 2008; DOI: 10.1093/jnci/djn190

Cite This Page:

Journal of the National Cancer Institute. "Multiple Regions Of Chromosome 8 Found To Be Associated With Different Cancers." ScienceDaily. ScienceDaily, 26 June 2008. <www.sciencedaily.com/releases/2008/06/080625112310.htm>.
Journal of the National Cancer Institute. (2008, June 26). Multiple Regions Of Chromosome 8 Found To Be Associated With Different Cancers. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2008/06/080625112310.htm
Journal of the National Cancer Institute. "Multiple Regions Of Chromosome 8 Found To Be Associated With Different Cancers." ScienceDaily. www.sciencedaily.com/releases/2008/06/080625112310.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins