Featured Research

from universities, journals, and other organizations

Genetic Variant Increases Triglyceride Levels In Asian-Americans

Date:
July 18, 2008
Source:
American Society for Biochemistry and Molecular Biology
Summary:
A genetic variant found almost exclusively in individuals of Asian descent increases the risk of elevated plasma triglycerides over four-fold. In fact, all 11 subjects who carried both copies of this rare variant for apolipoprotein A-V had extremely high and dangerous triglyceride levels in their blood.

A genetic variant found almost exclusively in individuals of Asian descent increases the risk of elevated triglycerides over four-fold, reports a comprehensive study in the Journal of Lipid Research. In fact, all 11 subjects who carried both copies of this rare variant for apolipoprotein A-V had extremely high and dangerous triglyceride levels in their blood.

Apolipoprotein A-V is a recently discovered lipid-binding protein that likely plays an important role in metabolizing triglycerides. Some population studies with groups in China and Taiwan indicate that a polymorphism in the APOA5 gene (553 G>T shift) is associated with elevated plasma TG levels, which like cholesterol, increase the risk of heart disease.

To get a broader view of this potentially important gene polymorphism, Clive Pullinger and colleagues examined the frequency and impact of this variant in a population of Chinese-Americans, as well as four other Asian-American populations (Japanese, Korean, Southeast Asian, and Pacific Islander).

The researchers examined 541 individuals and found that 15.1% of Chinese-Americans with high plasma TG (>150 mg/dl) carried at least one copy of the 553T variant, compared with only 3.7% of those with normal TG levels; in non-Chinese Asians these values were 13.7% and 5.4%. When calculated, the 553T variant corresponds to a 4.4 and 2.5 times greater risk of elevated TG in Chinese-Americans and other Asians, respectively.

The frequency became even more prevalent at higher levels; 60% of individuals with TG of >500 mg/dl carried the variant, and at 1000 mg/dl the frequency rose to 80%. And the 11 subjects who had the variant in both copies of their APOA5 gene had an average TG concentration of over 2000 mg/dl, which can pose serious health risks.

This specific genetic change seems restricted to Asians, as the researchers studied 779 non-Asian subjects and found only 3 incidences of the 553T variant (2 Caucasian and 1 Hispanic).


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Pullinger et al. An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients. The Journal of Lipid Research, 2008; 49 (8): 1846 DOI: 10.1194/jlr.P800011-JLR200

Cite This Page:

American Society for Biochemistry and Molecular Biology. "Genetic Variant Increases Triglyceride Levels In Asian-Americans." ScienceDaily. ScienceDaily, 18 July 2008. <www.sciencedaily.com/releases/2008/07/080717110234.htm>.
American Society for Biochemistry and Molecular Biology. (2008, July 18). Genetic Variant Increases Triglyceride Levels In Asian-Americans. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2008/07/080717110234.htm
American Society for Biochemistry and Molecular Biology. "Genetic Variant Increases Triglyceride Levels In Asian-Americans." ScienceDaily. www.sciencedaily.com/releases/2008/07/080717110234.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Fauci: Ebola Protocols to Focus on Training

Fauci: Ebola Protocols to Focus on Training

AP (Oct. 20, 2014) Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, says he expects revised CDC protocols on Ebola to focus on training, observation and ensuring health care workers are more protected. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins