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ShareScienceDaily (July 17, 2008) — Researchers from Utrecht University, The Netherlands, have developed a model that illustrates how HIV evades the immune system. The study incorporates detailed interactions between a mutating virus and the immune system.
HIV avoids recognition by the human immune response through the generation of viral variants called "escape mutants". This avoidance seems to thwart effective control of virus replication, causing HIV-infected patients to progress to AIDS. However, it remains difficult to fully understand the dynamics of immune escape, as data from infected patients is relatively sparse.
Knowing this, Drs. Christian Althaus and Rob De Boer performed computer simulations to help interpret longitudinal data derived from HIV-infected patients. They illustrate that the virus often evades the immune response very slowly, on a timescale of years.
Depending on the diversity of the immune system, the virus will either be controlled effectively or accumulate detrimental mutations.
The results suggest an alternative strategy of vaccine design could be to reduce the replicative capacity of the virus.
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The above story is reprinted from materials provided by Public Library of Science, via EurekAlert!, a service of AAAS.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Althaus et al. Dynamics of Immune Escape during HIV/SIV Infection. PLoS Computational Biology, 2008; 4 (7): e1000103 DOI: 10.1371/journal.pcbi.1000103
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
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