Featured Research

from universities, journals, and other organizations

'Snow Flea Antifreeze Protein' Could Help Improve Organ Preservation

Date:
July 25, 2008
Source:
American Chemical Society
Summary:
Scientists can now make the antifreeze protein that enables billions of Canadian snow fleas to survive frigid winter temperatures. Their laboratory-produced first-of-a-kind proteins could have practical uses in extending the storage life of donor organs and tissues for human transplantation, according to new research.

By creating an antifreeze protein found in the Canadian snow flea, scientists are reporting a development that could extend the storage life of donor organs. The figure shows representations of the unprecedented structure of the protein in its mirror image forms prepared by total chemical synthesis.
Credit: Courtesy of Brad Pentelute

Scientists in Illinois and Pennsylvania are reporting development of a way to make the antifreeze protein that enables billions of Canadian snow fleas to survive frigid winter temperatures. Their laboratory-produced first-of-a-kind proteins could have practical uses in extending the storage life of donor organs and tissues for human transplantation, according to new research.

Related Articles


In the study, Stephen B. H. Kent and colleagues point out that scientists have tried for years to decipher the molecular structure and produce from chemicals in a laboratory the so-called "snow flea antifreeze protein (sfAFP)." Those steps are critical for obtaining larger amounts of the protein, which exists naturally in only minute quantities in snow fleas. The larger synthetic quantities can be used for further research and potential medical and commercial uses, they say.

The researchers made synthetic sfAFP, and showed that it has the same activity as the natural protein. They also produced variants, including one form of sfAFP with a molecular architecture that is the reverse, or "mirror image," of natural sfAFP and different from any other protein found in living things on Earth.

The mirror-image form of sfAFP appears less likely to trigger harmful antibodies and more resistant to destruction by natural enzymes, making it potentially more effective than the native form for use in organ and tissue preservation, the scientists note. "Our most significant advance was the use of the two mirror image forms of the protein to determine the previously unknown crystal structure of this unique protein," said Kent. "That is a first in the history of protein X-ray crystallography."



Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Pentelute et al. Mirror Image Forms of Snow Flea Antifreeze Protein Prepared by Total Chemical Synthesis Have Identical Antifreeze Activities. Journal of the American Chemical Society, 2008; 0 (0): 0 DOI: 10.1021/ja801352j

Cite This Page:

American Chemical Society. "'Snow Flea Antifreeze Protein' Could Help Improve Organ Preservation." ScienceDaily. ScienceDaily, 25 July 2008. <www.sciencedaily.com/releases/2008/07/080721093707.htm>.
American Chemical Society. (2008, July 25). 'Snow Flea Antifreeze Protein' Could Help Improve Organ Preservation. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2008/07/080721093707.htm
American Chemical Society. "'Snow Flea Antifreeze Protein' Could Help Improve Organ Preservation." ScienceDaily. www.sciencedaily.com/releases/2008/07/080721093707.htm (accessed April 19, 2015).

Share This


More From ScienceDaily



More Matter & Energy News

Sunday, April 19, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

At Least 15 Injured in a California Natural Gas Pipeline Explosion

At Least 15 Injured in a California Natural Gas Pipeline Explosion

Reuters - US Online Video (Apr. 18, 2015) At least 15 injred after natural gas transmission line ruptures in Fresno, California. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
NASA Electric Rover Goes for a Spin

NASA Electric Rover Goes for a Spin

Reuters - Innovations Video Online (Apr. 17, 2015) NASA&apos;s prototype electric buggy could influence future space rovers and conventional cars. Jim Drury reports. Video provided by Reuters
Powered by NewsLook.com
Scientists Create Self-Powering Camera

Scientists Create Self-Powering Camera

Reuters - Innovations Video Online (Apr. 17, 2015) American scientists build a self-powering camera that captures images without using an external power source, allowing it to operate indefinitely in a well-lit environment. Elly Park reports. Video provided by Reuters
Powered by NewsLook.com
The State Of Virtual Reality

The State Of Virtual Reality

Newsy (Apr. 17, 2015) Virtual Reality is still a young industry. What’s on offer and what should we expect from our immersive new future? Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins