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Parasitic Worm Infections Increase Susceptibility To AIDS Viruses

Date:
July 24, 2008
Source:
Public Library of Science
Summary:
Persons infected with schistosomes, and possibly other parasitic worm infections, may be more likely to become infected with HIV than persons without worm infections, according to a new study. Researchers found that the infectious dose of an HIV-like virus necessary to infect rhesus macaques was 17-fold lower in animals with acute schistosomiasis than in controls.

Persons infected with schistosomes, and possibly other parasitic worm infections, may be more likely to become infected with HIV than persons without worm infections, according to a new study.

Researchers at the U.S. Centers for Disease Control and Prevention (Atlanta, United States) and the Dana-Farber Cancer Institute and Harvard Medical School (Boston, United States) found that the infectious dose of an HIV-like virus necessary to infect rhesus macaques was 17-fold lower in animals with acute schistosomiasis than in controls.

The study represents a novel in vivo demonstration that parasitic worms increase a host's susceptibility to becoming infected with an AIDS-causing virus. The macaques co-infected with Schistosoma mansoni also demonstrated higher peak viral loads and higher memory cell concentrations of virus, both predictors of more rapid progression to AIDS. These findings are consistent with the hypothesis that persons living in areas highly endemic for parasitic worms may also have a higher risk of acquiring HIV/AIDS.

Previous studies by this and other research groups have demonstrated that presence of schistosome infections increases viral replication in animal or human hosts with established immunodeficiency virus infections. The earlier findings, combined with the increased susceptibility to AIDS virus transmission shown in this study, may have profound public health implications for areas of the world where both parasitic worms and HIV-1 are endemic.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chenine A-L, Shai-Kobiler E, Steele LN, Ong H, Augostini P, et al. Acute Schistosoma mansoni Infection Increases Susceptibility to Systemic SHIV Clade C Infection in Rhesus Macaques after Mucosal Virus Exposure. PLoS Neglected Tropical Diseases, 2(7): e265 DOI: 10.1371/journal.pntd.0000265

Cite This Page:

Public Library of Science. "Parasitic Worm Infections Increase Susceptibility To AIDS Viruses." ScienceDaily. ScienceDaily, 24 July 2008. <www.sciencedaily.com/releases/2008/07/080722225346.htm>.
Public Library of Science. (2008, July 24). Parasitic Worm Infections Increase Susceptibility To AIDS Viruses. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2008/07/080722225346.htm
Public Library of Science. "Parasitic Worm Infections Increase Susceptibility To AIDS Viruses." ScienceDaily. www.sciencedaily.com/releases/2008/07/080722225346.htm (accessed April 23, 2014).

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