Featured Research

from universities, journals, and other organizations

New Insights Into The Regulation Of PTEN Tumor Suppression Function

Date:
August 23, 2008
Source:
Beth Israel Deaconess Medical Center
Summary:
New findings define a pathway that maintains PTEN in the nucleus and offer a novel target for enhancing this gene's tumor suppressive function.

The PTEN tumor suppressor gene controls numerous biological processes including cell proliferation, cell growth and death. But PTEN is frequently lost or mutated; in fact, alteration of the gene is so common among various types of human cancer that PTEN has become one of the most frequently mutated of all tumor suppressors.

Now, a study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School provides important new insights into PTEN regulation. Reported in the August 20 advance on-line issue of Nature, the findings define a pathway that maintains PTEN in the nucleus and offer a novel target for enhancing this gene's tumor suppressive function.

"Our laboratory recently discovered that even when PTEN is produced normally by a cell, it has to be properly localized within the nucleus in order to maintain its full tumor suppressive abilities," explains senior author Pier Paolo Pandolfi, MD, PhD, Director of Basic Research in BIDMC's Cancer Center and Professor of Medicine at Harvard Medical School. "Indeed, it's been demonstrated that in a variety of cancers, PTEN has broken away from the nucleus. With these new findings, we now understand how this happens."

Examination of the abnormal blood cells of acute promyelocytic leukemia (APL) led to the discovery that PTEN had become loosened from the nucleus.

"From there, we observed that the loss of another tumor suppressor known as PML [whose mutation is a main cause of acute promyelocytic leukemia] was at the root of PTEN's escape from the nucleus," adds the study's first author Min Sup Song, PhD, a member of the Pandolfi laboratory. Further investigations revealed that PML was blocking the function of an enzyme known as HAUSP, which under normal circumstances, serves to direct PTEN out of the nucleus.

"We discovered that this pathway is disrupted through the loss or mutation of PML, as well as through unchecked HAUSP expression, either of which can force PTEN from the nucleus and prevent its ability to act as a tumor suppressor," notes Pandolfi.

"The modulation of the PML-HAUSP pathway offers us an exciting and unique approach to enhancing the tumor suppressive actions of PTEN," he adds. "Because PML is known to be 'druggable,' we believe that in cases of APL, modulation of PTEN function can be achieved with drugs already being used for the treatment of human cancers, including interferon and all trans-retinoic acid."

This study was supported, in part, by grants from the National Institutes of Health International Human Frontier Science Program Organization and the European Molecular Biology Organization.

In addition to Pandolfi and Song, study coauthors include BIDMC investigators Leonardo Salmena, Arkaitz Carracedo, and Ainara Egia; Francesco Lo-Coco of the University of Tor Vergata, Italy; and Julie Teruya-Feldstein of Memorial Sloan-Kettering Cancer Center, New York.


Story Source:

The above story is based on materials provided by Beth Israel Deaconess Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Beth Israel Deaconess Medical Center. "New Insights Into The Regulation Of PTEN Tumor Suppression Function." ScienceDaily. ScienceDaily, 23 August 2008. <www.sciencedaily.com/releases/2008/08/080820162954.htm>.
Beth Israel Deaconess Medical Center. (2008, August 23). New Insights Into The Regulation Of PTEN Tumor Suppression Function. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2008/08/080820162954.htm
Beth Israel Deaconess Medical Center. "New Insights Into The Regulation Of PTEN Tumor Suppression Function." ScienceDaily. www.sciencedaily.com/releases/2008/08/080820162954.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins