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Vaginal Proteins In HIV-resistant Prostitutes Suggest New Prevention Measures

Date:
September 2, 2008
Source:
American Chemical Society
Summary:
Researchers in Canada report discovery of unusual proteins in a small group of Kenyan sex workers that appear to be associated with resistance to infection with HIV, the virus that causes AIDS.

Researchers in Canada report discovery of unusual proteins in a small group of Kenyan sex workers that appear to be associated with resistance to infection with HIV, the virus that causes AIDS.

The discovery could lead to the improved design of vaccines and drugs to fight the deadly virus, which infects an estimated 40 million people worldwide, the scientists say in a new report.

In the new study, Adam Burgener and colleagues note that 140 of more than 2000 sex workers studied in Nairobi, Kenya, appear resistant to HIV infection. Although evidence suggests that certain biological factors in their vaginal fluid may play a role in resistance, the exact identity of these substances was unclear.

The scientists used a high-tech analytical method to compare differences among proteins in vaginal fluids from HIV-resistant women and those infected with the virus or susceptible to it. HIV-resistant women had proteins significantly different from other women. Vaginal fluids of the HIV-resistant women had higher levels of proteins with anti-viral and anti-inflammatory actions.

These proteins could be used as the basis for new medications to prevent infection, the scientists suggest.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Burgener et al. Identification of Differentially Expressed Proteins in the Cervical Mucosa of HIV-1-Resistant Sex Workers. Journal of Proteome Research, 2008; 0 (0): 0 DOI: 10.1021/pr800406r

Cite This Page:

American Chemical Society. "Vaginal Proteins In HIV-resistant Prostitutes Suggest New Prevention Measures." ScienceDaily. ScienceDaily, 2 September 2008. <www.sciencedaily.com/releases/2008/09/080901205622.htm>.
American Chemical Society. (2008, September 2). Vaginal Proteins In HIV-resistant Prostitutes Suggest New Prevention Measures. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2008/09/080901205622.htm
American Chemical Society. "Vaginal Proteins In HIV-resistant Prostitutes Suggest New Prevention Measures." ScienceDaily. www.sciencedaily.com/releases/2008/09/080901205622.htm (accessed August 1, 2014).

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