Featured Research

from universities, journals, and other organizations

Virology: How Does Herpes Simplex Virus Cause Inflammation Of The Brain?

Date:
September 6, 2008
Source:
Journal of Clinical Investigation
Summary:
Worldwide, about 80% of young adults are infected with herpes simplex virus type 1 (HSV-1). The most common symptom of infection is a cold sore, but in some individuals the virus can also cause life-threatening inflammation of the brain (encephalitis); 70% of individuals who do not get treatment for this condition die.

Worldwide, about 80% of young adults are infected with herpes simplex virus type 1 (HSV-1).

The most common symptom of infection is a cold sore, but in some individuals the virus can also cause life-threatening inflammation of the brain (encephalitis); 70% of individuals who do not get treatment for this condition die.

New insight into the cellular proteins that the virus exploits to replicate itself and cause death from encephalitis has now been provided by a team of researchers at the National Cheng Kung University and the National Chiayi University, in the Republic of China, who analyzed human cell lines and mice infected with HSV-1.

In the study, expression of a cellular protein known as Egr1 was found to be increased after a human nerve cell line was infected with HSV-1. Further, Egr1 was shown to increase replication of the virus. Increased expression of Egr1 was also observed in the brain of mice infected with HSV-1.

Importantly, two different approaches to decrease Egr1 expression in the brain reduced the number of mice that died as a result of HSV-1 encephalitis, and this was associated with decreased numbers of viruses in the mice.

The authors therefore suggest that these data provide rationale for further studies to test whether blocking Egr1 could be a new strategy for preventing HSV-1–induced encephalitis and other conditions.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Suppression of transcription factor early growth response 1 reduces herpes simplex virus lethality in mice. Journal of Clinical Investigation, September 2, 2008

Cite This Page:

Journal of Clinical Investigation. "Virology: How Does Herpes Simplex Virus Cause Inflammation Of The Brain?." ScienceDaily. ScienceDaily, 6 September 2008. <www.sciencedaily.com/releases/2008/09/080902221735.htm>.
Journal of Clinical Investigation. (2008, September 6). Virology: How Does Herpes Simplex Virus Cause Inflammation Of The Brain?. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2008/09/080902221735.htm
Journal of Clinical Investigation. "Virology: How Does Herpes Simplex Virus Cause Inflammation Of The Brain?." ScienceDaily. www.sciencedaily.com/releases/2008/09/080902221735.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins