Featured Research

from universities, journals, and other organizations

Virology: How Does Herpes Simplex Virus Cause Inflammation Of The Brain?

Date:
September 6, 2008
Source:
Journal of Clinical Investigation
Summary:
Worldwide, about 80% of young adults are infected with herpes simplex virus type 1 (HSV-1). The most common symptom of infection is a cold sore, but in some individuals the virus can also cause life-threatening inflammation of the brain (encephalitis); 70% of individuals who do not get treatment for this condition die.

Worldwide, about 80% of young adults are infected with herpes simplex virus type 1 (HSV-1).

Related Articles


The most common symptom of infection is a cold sore, but in some individuals the virus can also cause life-threatening inflammation of the brain (encephalitis); 70% of individuals who do not get treatment for this condition die.

New insight into the cellular proteins that the virus exploits to replicate itself and cause death from encephalitis has now been provided by a team of researchers at the National Cheng Kung University and the National Chiayi University, in the Republic of China, who analyzed human cell lines and mice infected with HSV-1.

In the study, expression of a cellular protein known as Egr1 was found to be increased after a human nerve cell line was infected with HSV-1. Further, Egr1 was shown to increase replication of the virus. Increased expression of Egr1 was also observed in the brain of mice infected with HSV-1.

Importantly, two different approaches to decrease Egr1 expression in the brain reduced the number of mice that died as a result of HSV-1 encephalitis, and this was associated with decreased numbers of viruses in the mice.

The authors therefore suggest that these data provide rationale for further studies to test whether blocking Egr1 could be a new strategy for preventing HSV-1–induced encephalitis and other conditions.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Suppression of transcription factor early growth response 1 reduces herpes simplex virus lethality in mice. Journal of Clinical Investigation, September 2, 2008

Cite This Page:

Journal of Clinical Investigation. "Virology: How Does Herpes Simplex Virus Cause Inflammation Of The Brain?." ScienceDaily. ScienceDaily, 6 September 2008. <www.sciencedaily.com/releases/2008/09/080902221735.htm>.
Journal of Clinical Investigation. (2008, September 6). Virology: How Does Herpes Simplex Virus Cause Inflammation Of The Brain?. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2008/09/080902221735.htm
Journal of Clinical Investigation. "Virology: How Does Herpes Simplex Virus Cause Inflammation Of The Brain?." ScienceDaily. www.sciencedaily.com/releases/2008/09/080902221735.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com
Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins