Featured Research

from universities, journals, and other organizations

Gaining A Better Understanding Of Kidney Diseases

Date:
September 8, 2008
Source:
Helmholtz Association of German Research Centres
Summary:
By introducing a genetic switch in mice it is possible to increase or decrease the production of specific protein molecules in their kidneys. Thus, researchers can study the influence of specific proteins on disease development. This model of investigating severe kidney diseases was published in Nature Medicine.

By introducing a genetic switch in mice it is possible to increase or decrease the production of specific protein molecules in their kidneys. Thus, researchers can study the influence of specific proteins on disease development.

Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Heidelberg University Hospitals and other research institutes have published this model of investigating severe kidney diseases in the latest issue of Nature medicine.

Cystic kidney disease, renal fibrosis, or renal cell carcinoma: Many diseases of the excretory organs are characterized by overproduction or – on the contrary – absence of characteristic proteins in the renal cells. An international research team under the leadership of scientists from DKFZ and Heidelberg University Hospitals has now developed an animal model to better investigate these conditions.

The researchers introduced a genetic switch into the genome of mice. This switch allows to selectively turn on and off the production of disease-typical proteins in renal tissue. It is activated simply by adding the antibiotic tetracycline to the animal food.

To find out whether it is possible to study the development of kidney diseases in the genetically modified (transgenic) animals, the investigators stimulated the production of c-Myc in the renal tissue of the mice. Numerous tumors have been reported to be associated with elevated levels of this transcription factor. Shortly after activation of the c-Myc gene the animals started developing cysts that led to organ failure. Pathologists also discovered renal cell carcinomas in some of the mice. As a reaction to the overexpression of another signaling molecule, the mice developed renal fibrosis.

Earlier attempts to study disease development using transgenic animals have often failed because the proteins to be studied are overproduced in the murine embryos already. As a result, the animals often develop severe malformations that make meaningful conclusions impossible. “A particular advantage of our model is that we can switch on and off disease-typical renal proteins at any given time,” explained Associate Professor (PD) Dr. Robert Kösters of the Institute of Human Genetics of the University of Heidelberg and Professor Dr. Hermann-Josef Gröne of the German Cancer Research Center. “Thus, we are able to simulate the natural course of disease development and also of healing processes.”

Milena Traykova-Brauch, Kai Schönig, Oliver Greiner, Tewfik Miloud, Anna Jauch, Manja Bode, Dean W Felsher, Adam B Glick, David J Kwiatkowski, Hermann Bujard, Jürgen Horst, Magnus von Knebel Doeberitz, Felix K Niggli, Wilhelm Kriz, Hermann-Josef Gröne and Robert Koesters: An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice. Nature medicine, 24 August 2008

The task of the Deutsches Krebsforschungszentrum in Heidelberg (German Cancer Research Center, DKFZ) is to systematically investigate the mechanisms of cancer development and to identify cancer risk factors. The findings resulting from basic research are expected to lead to new approaches in the prevention, diagnosis, and treatment of cancer. Funding is provided by the Federal Ministry of Education and Research (BMBF; 90 percent) and by the State of Baden-Wuerttemberg (10 percent). The German Cancer Research Center is a member of the Helmholtz Association of National Research Centers (Helmholtz-Gemeinschaft Deutscher Forschungszentren e.V.).


Story Source:

The above story is based on materials provided by Helmholtz Association of German Research Centres. Note: Materials may be edited for content and length.


Cite This Page:

Helmholtz Association of German Research Centres. "Gaining A Better Understanding Of Kidney Diseases." ScienceDaily. ScienceDaily, 8 September 2008. <www.sciencedaily.com/releases/2008/09/080904102758.htm>.
Helmholtz Association of German Research Centres. (2008, September 8). Gaining A Better Understanding Of Kidney Diseases. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2008/09/080904102758.htm
Helmholtz Association of German Research Centres. "Gaining A Better Understanding Of Kidney Diseases." ScienceDaily. www.sciencedaily.com/releases/2008/09/080904102758.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) — America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) — A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins