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New Mechanism For Cardiac Arrhythmia Discovered

Date:
September 19, 2008
Source:
Helmholtz Association of German Research Centres
Summary:
Virus infections can cause cardiac arrhythmia. Scientists have now discovered the molecular mechanism. They have demonstrated that the receptor which the virus uses to infect heart cells is normally necessary for regular heart beat. Likewise, when the receptor is absent, arrhythmia occurs. The researchers assume that the virus infection and the autoimmune disease can block the receptor which disrupts the heart's normal rhythm.

It has long been thought that virus infections can cause cardiac arrhythmia. But why has not been understood. Ulrike Lisewski, Dr. Yu Shi, Michael Radke and Professor Michael Gotthardt of the Max Delbrόck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have now discovered the molecular mechanism.

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The researchers demonstrated that the receptor which the virus uses to infect heart cells is normally necessary for regular heart beat in mice. Likewise, when the receptor is absent or non-functioning, arrhythmia occurs. They assume that both the virus infection and the autoimmune disease can block the receptor which, in turn, disrupts the heart's normal rhythm.

The heart consists of two ventricles and two atria. In order to beat correctly and to pump blood through the body, specialized heart fibres generate electric signals that control the heart beat. Cardiac arrhythmia occurs when these signals are not correctly generated or forwarded. There, a receptor, which scientists call CAR, plays an important role.

CAR stands for Coxsackievirus-Adenovirus-Receptor. It is embedded in specific cell-cell-contacts (tight junctions) of the specialized heart fibres. CAR was discovered as the critical protein responsible for virus entry during infection with Coxsackie and Adenoviruses. Its role in the adult heart was previously unknown.

To investigate CAR's task in a healthy organism, the MDC-scientists switched off the CAR-gene in adult mice. As a result, the rodents could no longer produce the receptors and developed cardiac arrhythmia. "That is an interesting observation because these special cell-cell-contacts, the tight junctions, have not been connected to arrhythmia so far", Professor Gotthardt says.

A detailed analysis of the animals showed that the transfer of electric signals from the atria to the ventricles does not work properly. "When CAR is missing, the signal can not be passed on and the heart does not beat properly," Dr. Shi says.

Professor Gotthardt now wants to investigate whether CAR is blocked in patients with arrhythmia. "However, it does not always have to be connected to a virus infection," he says. "The body's own antibodies directed against CAR could cause the disease as well."


Story Source:

The above story is based on materials provided by Helmholtz Association of German Research Centres. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lisewski et al. The tight junction protein CAR regulates cardiac conduction and cell-cell communication. Journal of Experimental Medicine, 2008; DOI: 10.1084/jem.20080897

Cite This Page:

Helmholtz Association of German Research Centres. "New Mechanism For Cardiac Arrhythmia Discovered." ScienceDaily. ScienceDaily, 19 September 2008. <www.sciencedaily.com/releases/2008/09/080918101529.htm>.
Helmholtz Association of German Research Centres. (2008, September 19). New Mechanism For Cardiac Arrhythmia Discovered. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2008/09/080918101529.htm
Helmholtz Association of German Research Centres. "New Mechanism For Cardiac Arrhythmia Discovered." ScienceDaily. www.sciencedaily.com/releases/2008/09/080918101529.htm (accessed November 28, 2014).

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