Featured Research

from universities, journals, and other organizations

Resistance to TB Vaccine May Be Uncommon, Protects Against Nine Strains in Mice

Date:
November 28, 2008
Source:
American Society for Microbiology
Summary:
A new study shows that the current tuberculosis vaccine induces protective immunity against nine strains of the bacteria in mice indicating that strain-specific resistance may be uncommon.

A new study shows that the current tuberculosis vaccine induces protective immunity against nine strains of the bacteria in mice indicating that strain-specific resistance may be uncommon.

Related Articles


Tuberculosis (TB) is one of the world's most challenging infectious diseases to date and is responsible for approximately 2 million deaths per year. An attenuated vaccine incorporating Mycobacterium bovis BCG has been used for over 50 years, however, high mortality rates have persisted and researchers attribute multiple factors to its varying effectiveness including that the anti-TB protective immunity induced by the vaccine may be strain-specific.

W-Beijing lineage strains are among the most prominent associated with worldwide outbreaks of TB. In the study researchers investigated the strain specificity of Mycobacterium bovis BCG vaccine-induced antituberculosis protective immunity responses by inoculating mice with the vaccine and challenging them 2 months later with one of nine Mycobacterium tuberculosis strains, four from the W-Beijing lineage, four non-Beijing isolates, and one control.

Organ bacterial burdens and lung pathology were examined in vaccinated and naοve mice the day of infection as well as at 4, 12, and 20 weeks postchallenge. Four weeks following an aerosol challenge with each of the strains, results showed the bacterial growth in the lungs and spleens were much lower and lung pathology significantly improved in all vaccinated animals when compared to controls. Animals infected with six of the nine strains exhibited reduced organ bacterial burdens after 12 weeks and lung inflammation in all immunized animals was measurably lower at 20 weeks postchallenge.

"These data demonstrate that BCG vaccination protects against infection with diverse M. tuberculosis strains in the mouse model of pulmonary tuberculosis and suggest that strain-specific resistance to BCG-induced protective immunity may be uncommon," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. (B.Y. Joen, S.C. Derrick, J. Lim, K. Kolibab, V. Dheenadhayalan, A.L. Yang, B. Kreiswirth, S.L. Morris. Mycobacterium bovis BCG immunization induces protective immunity against nine different Mycobacterium tuberculosis strains in mice. Infection and Immunity, 76. 11: 5173-5180

Cite This Page:

American Society for Microbiology. "Resistance to TB Vaccine May Be Uncommon, Protects Against Nine Strains in Mice." ScienceDaily. ScienceDaily, 28 November 2008. <www.sciencedaily.com/releases/2008/11/081125161535.htm>.
American Society for Microbiology. (2008, November 28). Resistance to TB Vaccine May Be Uncommon, Protects Against Nine Strains in Mice. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2008/11/081125161535.htm
American Society for Microbiology. "Resistance to TB Vaccine May Be Uncommon, Protects Against Nine Strains in Mice." ScienceDaily. www.sciencedaily.com/releases/2008/11/081125161535.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) — The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins