Featured Research

from universities, journals, and other organizations

Transplanted Fat Cells Restore Function After Spinal Cord Injury

Date:
December 11, 2008
Source:
Cell Transplantation
Summary:
Fat cells, plentiful and easily obtained from adipose tissues without discomfort and grown under culture conditions as de-differentiated fat cells (DFAT), have been for the first time shown to successfully differentiate into neuronal cells in in vivo tests.

A new study suggests that mature adipocytes - fat cells - could become a source for cell replacement therapy to treat central nervous system disorders.

Related Articles


According to the study's lead researcher, Dr. Yuki Ohta of the Institute of Medical Science, St. Mariana University School of Medicine, Kawasaki, Japan, adipose-derived stem/stromal cells have in the past been shown to differentiate into neuronal cells in an in vitro setting. In their study, for the first time fat cells have been shown to successfully differentiate into neuronal cells in in vivo tests. The fat cells are grown under culture conditions that result in them becoming de-differentiated fat (DFAT) cells.

"These cells, called DFAT cells, are plentiful and can be easily obtained from adipose tissue without discomfort and represent autologous (same patient) tissue," said Ohta. "DFAT cells, with none of the features of adipocytes, do have the potential to differentiate into endothelial, neuronal or glial lineages."

The research team reported that DFAT cells expressed neurotrophic factors, such as BDNF and GDNF, prior to and after transplantation and which likely contributed to the promotion of functional recovery.

According to Ohta and colleagues, tests in animal models confirmed that the injected cells survived without the aid of immunosuppression drugs and that the DFAT-grafted animals showed significantly better motor function than controls.

"We concluded that DFAT-derived neurotrophic factors contributed to promotion of functional recovery after spinal cord injury (SCI)," said Ohta. "Transplanting DFAT cells into SCI rats significantly promoted the recovery of their hind limb function."

"These studies demonstrate the ability to obtain stem cells from a patient's own fat that can help repair injury to the spinal cord," said Paul R. Sanberg, PhD, DSc, at the University of South Florida Health, and Coeditor-in-chief of Cell Transplantation.

This study was published Cell Transplantation(Vol.17, No. 8.)


Story Source:

The above story is based on materials provided by Cell Transplantation. Note: Materials may be edited for content and length.


Cite This Page:

Cell Transplantation. "Transplanted Fat Cells Restore Function After Spinal Cord Injury." ScienceDaily. ScienceDaily, 11 December 2008. <www.sciencedaily.com/releases/2008/12/081210122254.htm>.
Cell Transplantation. (2008, December 11). Transplanted Fat Cells Restore Function After Spinal Cord Injury. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2008/12/081210122254.htm
Cell Transplantation. "Transplanted Fat Cells Restore Function After Spinal Cord Injury." ScienceDaily. www.sciencedaily.com/releases/2008/12/081210122254.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Newsy (Apr. 17, 2015) Ten doctors signed a letter urging Columbia University to drop Dr. Oz as vice chair of its department of surgery, saying he plugs "quack" treatments. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins