Featured Research

from universities, journals, and other organizations

'Bliss' Blocks Sperm: Investigating Impact Of Marijuana Exposure On Male Infertility

Date:
January 23, 2009
Source:
Society for the Study of Reproduction
Summary:
Evidence suggests that human male fertility is impacted by long-term exposure to marijuana. Indeed, endocannabinoids and their receptors are present in the male reproductive tract, further suggesting a functional role in fertility, but there has been no genetic test to clarify mechanisms. Now researchers have characterized the phenotype of mice genetically lacking FAAH, fatty acid amide hydrolase.

Evidence suggests that human male fertility is impacted by long-term exposure to marijuana. Indeed, endocannabinoids and their receptors are present in the male reproductive tract, further suggesting a functional role in fertility, but there has been no genetic test to clarify mechanisms.

Now, in a paper the February 2009 issue of the journal Biology of Reproduction, Sun et al. characterize the phenotype of mice genetically lacking FAAH, fatty acid amide hydrolase.

Male mice homozygous for the Faah knockout have elevated levels of anandamide, an endocannabinoid, in the reproductive system, and their sperm have decreased ability to fertilize due to poor penetration of the egg's zona pellucida. These results point to previously unsuspected pathways regulating sperm function.

But perhaps more importantly, they are of great clinical significance: because sperm of chronic marijuana users, as well as sperm in Faah-mutant males are exposed to enhanced cannabinoid/endocannbinoid signaling, clinically beneficial effects of anandamide must be weighed against potentially harmful effects on fertility.

(Note: The term anandamide for the endocannabinoid arachidonoylethanolamide was coined by the discoverer of this compound, Dr. Mechoulam; "ananda" means bliss or ecstasy.)


Story Source:

The above story is based on materials provided by Society for the Study of Reproduction. Note: Materials may be edited for content and length.


Journal Reference:

  1. Xiaofei Sun, Haibin Wang, Masaru Okabe, Kenneth Mackie, Philip J. Kingsley, Lawrence Marnett, Benjamin Cravatt, and Sudhansu K. Dey. Genetic Loss of Faah Compromises Male Fertility in Mice. Biology of Reproduction, 2008; DOI: 10.1095/biolreprod.108.072736

Cite This Page:

Society for the Study of Reproduction. "'Bliss' Blocks Sperm: Investigating Impact Of Marijuana Exposure On Male Infertility." ScienceDaily. ScienceDaily, 23 January 2009. <www.sciencedaily.com/releases/2009/01/090121214131.htm>.
Society for the Study of Reproduction. (2009, January 23). 'Bliss' Blocks Sperm: Investigating Impact Of Marijuana Exposure On Male Infertility. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2009/01/090121214131.htm
Society for the Study of Reproduction. "'Bliss' Blocks Sperm: Investigating Impact Of Marijuana Exposure On Male Infertility." ScienceDaily. www.sciencedaily.com/releases/2009/01/090121214131.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Ebola Patient Told Hospital He Was from Liberia

Ebola Patient Told Hospital He Was from Liberia

AP (Oct. 1, 2014) The first Ebola patient diagnosed in the U.S. initially went to a Dallas emergency room last week but was sent home, despite telling a nurse that he had been in disease-ravaged West Africa, the hospital acknowledged Wednesday. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins