Featured Research

from universities, journals, and other organizations

Human Metapneumovirus Infection Predisposes Mice To Severe Pneumococcal Pneumonia

Date:
January 29, 2009
Source:
American Society for Microbiology
Summary:
A new study suggests that prior infection with human metapneumovirus or influenza A virus predisposes mice to a severe secondary bacterial infection with pneumococcal pneumonia.

A new study suggests that prior infection with human metapneumovirus or influenza A virus predisposes mice to a severe secondary bacterial infection with pneumococcal pneumonia. The researchers from the Universitaire de Quebec and Laval University, Quebec, Canada and Virion Systems, Inc., Rockville, Maryland, report their findings in the Journal of Virology.

A newly discovered member of the Paramyxoviridae family, human metapneumovirus (hMPV) has been associated with upper and lower respiratory tract symptoms such as common colds, bronchitis, and pneumonia. Previous studies suggest that hMPV infects virtually all individuals worldwide by the age of 5 resulting in a significant number of hospitalizations of young children. Research on co-infecting pathogens in hMPV-infected individuals has focused more exclusively on other viruses, however some instances of bacterial coinfections in hMPV infected individuals have been reported.

In the study researchers compared the response of mice initially infected with hMPV or influenza A virus followed by superinfection with Streptococcus pneumoniae 5 days later to mice infected with hMPV, influenza virus, or pneumococcus alone. Results showed that superinfected mice suffered significant weight loss and greater levels of airway obstruction than those mice only infected with hMPV, influenza, or pneumococcus. Bacterial counts increased in superinfected mice and higher rates of interstitial and alveolar inflammation were also observed.

"Prior infection with either hMPV or influenza A virus predisposes mice to severe pneumococcus infection," say the researchers. "Our results stress the importance of the conjugate pneumococcal vaccine in reducing the severity of hMPV and influenza virus infections by preventing pneumococcal superinfections."



Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kukavica-Ibrulj et al. Infection with Human Metapneumovirus Predisposes Mice to Severe Pneumococcal Pneumonia. Journal of Virology, 2008; 83 (3): 1341 DOI: 10.1128/JVI.01123-08

Cite This Page:

American Society for Microbiology. "Human Metapneumovirus Infection Predisposes Mice To Severe Pneumococcal Pneumonia." ScienceDaily. ScienceDaily, 29 January 2009. <www.sciencedaily.com/releases/2009/01/090127093208.htm>.
American Society for Microbiology. (2009, January 29). Human Metapneumovirus Infection Predisposes Mice To Severe Pneumococcal Pneumonia. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2009/01/090127093208.htm
American Society for Microbiology. "Human Metapneumovirus Infection Predisposes Mice To Severe Pneumococcal Pneumonia." ScienceDaily. www.sciencedaily.com/releases/2009/01/090127093208.htm (accessed September 22, 2014).

Share This



More Plants & Animals News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cat Lovers Flock to Los Angeles

Cat Lovers Flock to Los Angeles

AFP (Sep. 22, 2014) The best funny internet cat videos are honoured at LA's Feline Film Festival. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
Washed-Up 'Alien Hairballs' Are Actually Algae

Washed-Up 'Alien Hairballs' Are Actually Algae

Newsy (Sep. 22, 2014) Green balls of algae washed up on Sydney, Australia's Dee Why Beach. Video provided by Newsy
Powered by NewsLook.com
Raw: San Diego Zoo Welcomes Cheetah Cubs

Raw: San Diego Zoo Welcomes Cheetah Cubs

AP (Sep. 20, 2014) The San Diego Zoo has welcomed two Cheetah cubs to its Safari Park. The nearly three-week-old female cubs are being hand fed and are receiving around the clock care. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Chocolate Museum Opens in Brussels

Chocolate Museum Opens in Brussels

AFP (Sep. 19, 2014) Considered a "national heritage" in Belgium, chocolate now has a new museum in Brussels. In a former chocolate factory, visitors to the permanent exhibition spaces, workshops and tastings can discover derivatives of the cocoa bean. Duration: 01:00 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins