Featured Research

from universities, journals, and other organizations

Breaking The Barrier: Discovery Of Anti-resistance Factors And Novel Ocean Drugs

Date:
February 24, 2009
Source:
National Oceanic And Atmospheric Administration
Summary:
Investigations into coral disease, red tides and other marine environmental issues have led to discoveries of new chemicals as a source for pharmaceuticals. These chemicals function as antibiotics for microorganism providing survival advantages and may be usable in human health care. We believe that one could apply many of these chemical mechanisms or novel pharmaceuticals to human disease resulting in a number of alternatives to deal with growing antibiotic resistance.

Investigations into coral disease, red tides and other marine environmental issues have led to discoveries of new chemicals as a source for pharmaceuticals. These chemicals function as antibiotics for microorganism providing survival advantages and may be usable in human health care.

Research by scientists from NOAA's National Ocean Service, The Medical University of South Carolina and North Carolina State University has found several compounds which exhibit very strong antibiotic, antifungal, and antiviral potential as well as some anti-cancer and angiogenesis activities. The research into coral disease has resulted in thousands of new bacterial isolates producing highly selective antimicrobial compounds yielding highly selective small peptide antibiotics.

Many of these novel antibiotics are advantageous, as they demonstrate no cytotoxic responses to human cells and may minimize negative side effects associated with those drugs in current usage. The researchers have yet to find a "known" resistant bacteria that cannot be made re-susceptible to current generation antibiotics, offering extended use of current drugs. We believe that one could apply many of these chemical mechanisms or novel pharmaceuticals to human disease resulting in a number of alternatives to deal with growing antibiotic resistance.

Observations from the sponge Agelas conifera's ability to protect itself against fouling and disease have led to the discovery of ageliferin derivatives that demonstrate very strong anti-biofilm activity. Compounds with this specific activity hold promise to increase the efficacy of current and out of use antibiotics because of their ability to inhibit and/or disperse the protective layer that infectious agents often produce to protect themselves. Such compounds are also finding potential use in other areas of human health as well, including cystic fibrosis, chemo-therapy, anti-fungal agents, and for use in medical stints and prosthetics.

Marine natural products hold much promise in combating both the trend of antibiotic resistance but also to discover new antibiotics. The one-two punch of discovering new antibiotics as well as novel chemicals that make older generation drugs more effective represents cutting edge science addressing a critical need in human health care.


Story Source:

The above story is based on materials provided by National Oceanic And Atmospheric Administration. Note: Materials may be edited for content and length.


Cite This Page:

National Oceanic And Atmospheric Administration. "Breaking The Barrier: Discovery Of Anti-resistance Factors And Novel Ocean Drugs." ScienceDaily. ScienceDaily, 24 February 2009. <www.sciencedaily.com/releases/2009/02/090213161027.htm>.
National Oceanic And Atmospheric Administration. (2009, February 24). Breaking The Barrier: Discovery Of Anti-resistance Factors And Novel Ocean Drugs. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2009/02/090213161027.htm
National Oceanic And Atmospheric Administration. "Breaking The Barrier: Discovery Of Anti-resistance Factors And Novel Ocean Drugs." ScienceDaily. www.sciencedaily.com/releases/2009/02/090213161027.htm (accessed July 22, 2014).

Share This




More Plants & Animals News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

San Diego Zoo Welcomes New, Rare Rhino Calf

San Diego Zoo Welcomes New, Rare Rhino Calf

Reuters - US Online Video (July 21, 2014) An endangered black rhino baby is the newest resident at the San Diego Zoo. Sasha Salama reports. Video provided by Reuters
Powered by NewsLook.com
Shark Sightings a Big Catch for Cape Tourism

Shark Sightings a Big Catch for Cape Tourism

AP (July 21, 2014) A rise in shark sightings along the shores of Chatham, Massachusetts is driving a surge of eager vacationers to the beach town looking to catch a glimpse of a great white. (July 21) Video provided by AP
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
A Centuries' Old British Tradition Is Far from a Swan Song

A Centuries' Old British Tradition Is Far from a Swan Song

AFP (July 19, 2014) As if it weren't enough that the Queen is the Sovereign of the UK and 15 other Commonwealth realms, she is also the owner of all Britain's unmarked swans. Duration: 02:18 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins