Featured Research

from universities, journals, and other organizations

Type Of Vitamin B1 Could Treat Common Cause Of Blindness

Date:
April 27, 2009
Source:
University of Texas Medical Branch at Galveston
Summary:
Researchers have discovered that a form of vitamin B1 could become a new and effective treatment for one of the world's leading causes of blindness, uveitis.

University of Texas Medical Branch at Galveston researchers have discovered that a form of vitamin B1 could become a new and effective treatment for one of the world's leading causes of blindness.

Scientists believe that uveitis, an inflammation of the tissue located just below the outer surface of the eyeball, produces 10 to 15 percent of all cases of blindness in the United States, and causes even higher rates of blindness globally. The inflammation is normally treated with antibiotics or steroid eye drops.

In a paper appearing in the May issue of the journal Investigative Ophthalmology and Visual Science, however, the UTMB researchers describe striking results achieved with benfotiamene, a fat-soluble form of vitamin B1. In their experiments, they first injected laboratory rats with bacterial toxins that ordinarily produce a reaction mimicking uveitis. When those rats are fed benfotiamene, they fail to develop any signs of the inflammatory disorder.

"Benfotiamene strongly suppresses this eye-damaging condition and the biochemical markers we associate with it," said UTMB associate professor Kota V. Ramana, senior author of the study. "We're optimistic that this simple supplementation with vitamin B1 has great potential as a new therapy for this widespread eye disease."

The researchers' data shows benfotiamene works by suppressing the activation of a crucial signaling molecule called NF-kappa B, which is normally triggered by the stress caused by infection. Shutting down NF-kappa B, they said, prevents the runaway production of inflammatory proteins that generates uveitis.

Benfotiamene's low cost, rapid absorption by the body and lack of negative side effects make it an ideal candidate for uveitis prevention, according to Ramana.

"Already, clinical trials have shown that benfotiamene is absorbed better than thiamine [the most common form of vitamin B1] and significantly improved diabetic polyneuropathy in patients, and it's already taken as a supplement for diabetic complications," Ramana said.


Story Source:

The above story is based on materials provided by University of Texas Medical Branch at Galveston. Note: Materials may be edited for content and length.


Cite This Page:

University of Texas Medical Branch at Galveston. "Type Of Vitamin B1 Could Treat Common Cause Of Blindness." ScienceDaily. ScienceDaily, 27 April 2009. <www.sciencedaily.com/releases/2009/04/090423180237.htm>.
University of Texas Medical Branch at Galveston. (2009, April 27). Type Of Vitamin B1 Could Treat Common Cause Of Blindness. ScienceDaily. Retrieved October 19, 2014 from www.sciencedaily.com/releases/2009/04/090423180237.htm
University of Texas Medical Branch at Galveston. "Type Of Vitamin B1 Could Treat Common Cause Of Blindness." ScienceDaily. www.sciencedaily.com/releases/2009/04/090423180237.htm (accessed October 19, 2014).

Share This



More Health & Medicine News

Sunday, October 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins