Featured Research

from universities, journals, and other organizations

Examining TLR4 Influences Of B Cell Response

Date:
May 5, 2009
Source:
Boston University Medical Center
Summary:
Chronic inflammation, which is at the root of multiple diseases, links periodontal disease to increased incidence of cardiovascular disease.

Chronic inflammation, which is at the root of multiple diseases, links periodontal disease to increased incidence of cardiovascular disease.

The activation of Toll-Like Receptors, which are essential components of the immune response to certain pathogens, promotes chronic inflammation in periodontal disease. Of these receptors TLR4 is one of a family of receptors that provides critical links between immune stimulants produced by microorganisms and the host response. It stands out because it plays a key role in systemic inflammation by stimulating a type of white blood cells produced in bone marrow. Known as B cells they are the cornerstone of the body's antibody production system. The ability of pathogens that chronically infect the mouth to induce TLR4 responses indicates that TLR4 plays a role in the relationship between periodontal disease and cardiovascular disease.

The link between TLR4 activity and periodontal disease, and the importance of B cells in oral immunity prompted a team of Boston University School of Medicine (BUSM) researchers, led by Barbara Nikolajczyk, an associate professor of microbiology and medicine, and her co-investigator, Lisa Gnaley-Leal, an assistant professor of medicine and microbiology, to question whether B cells respond to chronic periodontal disease infection through TLR4.

Tests compared B cells from human blood collected from both healthy volunteers and patients with aggressive periodontitis but no other known disease. The study, published in the Journal of Leukocyte Biology, showed that people with periodontal disease had a higher percentage of peripheral blood and tissue B cells that expressed TLR4. These TLR4-expressing B cells harbored significant changes in the pathways located downstream of TLR4, including unexpected decreases in inflammatory gene expression. Decreased inflammatory gene expression in TLR4-expressing B cells is highly likely to alter the immune responses of periodontal disease patients during inflammation as compared to healthy individuals.

The study highlights two fundamentally different responses by TLR4-expressing cells from periodontal disease patients: activation of monocytes, a type of white blood cell that ingests bacteria and tissue debris, versus inactivation of B cells.

"Overall, these findings demonstrated that the proposed strategy of regulating systemic inflammation disease by regulating TLR4 expression/activation must account for this newly identified source of TLR4 activity, B cells," the study states.

In addition to Nikolajczyk, the authors of the study, "B cells from periodontal disease patients express surface Toll-like receptor 4,"are Hyunjin Shin, research assistant, and Yue Zhang, research associate, of the BUSM's department of microbiology, Madhumita Jagannathan, a graduate research assistant, at BUSM's Pathology Department, and Hatice Hasturk, Alpdogan Kantarci, both assistant professors and research assistant Hongsheng Liu and Professor Thomas E. Van Dyke, of the Department of Periodontology and Oral Biology at Boston University's Goldman School of Dental Medicine.


Story Source:

The above story is based on materials provided by Boston University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Boston University Medical Center. "Examining TLR4 Influences Of B Cell Response." ScienceDaily. ScienceDaily, 5 May 2009. <www.sciencedaily.com/releases/2009/05/090505153626.htm>.
Boston University Medical Center. (2009, May 5). Examining TLR4 Influences Of B Cell Response. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2009/05/090505153626.htm
Boston University Medical Center. "Examining TLR4 Influences Of B Cell Response." ScienceDaily. www.sciencedaily.com/releases/2009/05/090505153626.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins