Featured Research

from universities, journals, and other organizations

Intestinal Bacteria Associated With Non-alcoholic Fatty Liver Disease

Date:
May 31, 2009
Source:
Wiley-Blackwell
Summary:
Intestinal permeability and an overgrowth of bacteria in the small intestine are both associated with non-alcoholic fatty liver disease, according to new findings.

Intestinal permeability and an overgrowth of bacteria in the small intestine are both associated with nonalcoholic fatty liver disease (NAFLD). These findings are revealed in a new study in the June issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD).

Previous studies have suggested that bacteria from the intestine might play a role in NAFLD, which is the hepatic component of the Metabolic Syndrome. NAFLD can worsen to nonalcoholic steatohepatitis, and some experts have wondered if liver exposure to bacteria from the gut could promote this progression.

Researchers, led by Antonio Grieco of Rome , investigated gut permeability in patients with NAFLD and compared the results to patients with untreated celiac disease, who are known to be prone to this condition, and to healthy volunteers.

Their study included 35 patients with biopsy-confirmed NAFLD, 27 with celiac disease and 24 healthy volunteers. The researchers checked the level of small intestinal bacterial overgrowth in each participant using glucose breath testing. They assessed intestinal permeability by looking at urinary excretion of Cr-EDTA. And they examined the integrity of tight junctions within the gut through duodenal biopsies.

“The main findings of this study are that both intestinal permeability and the prevalence of small intestinal bacterial overgrowth are increased in patients with NAFLD and correlate with the severity of steatosis,” the authors report. “Disruption of tight junction integrity may explain the increased permeability in these patients.”

The authors hypothesize that small intestinal bacterial overgrowth and/or the associated increase in gut permeability may cause steatosis. This idea is supported by studies on mice, and by reports that probiotics can improve steatosis that is the result of a high fat diet.

Importantly, there was no association between either small intestinal bacterial overgrowth or intestinal permeability and steatohepatitis or fibrosis, which argues against a primary role for gut bacteria in the progression of NAFLD to more severe liver disease.

“In conclusion,” the authors write, “we have demonstrated that NAFLD is associated with increased intestinal permeability and small intestinal bacterial overgrowth and that these factors are associated with the severity of hepatic steatosis.” Further studies are needed to determine the exact causal relationship, and could lead to new therapies for NAFLD that address the microbiome of the gut.

An accompanying editorial by Elisabetta Bugianesi and Ester Vanni of the University of Turin applauds the new findings. “The authors were able to demonstrate both the presence of small intestinal bacterial overgrowth and of increased intestinal permeability in patients with NAFLD, providing the first demonstration of gut leakiness in NAFLD,” they write.

“The study by Luca Miele and colleagues raises the possibility that gut microbiota and intestine permeability are important mediators of diet-induced metabolic disturbances in NAFLD,” they conclude.

Lifestyle-focused therapy would be best for patients with NAFLD, Bugianesi and Vanni suggest, but manipulating gut flora by antibiotics, prebiotics, and probiotics could help counteract the effect of unbalanced diets on metabolic diseases.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal References:

  1. Miele, Luca; Valenza, Venanzio; La Torre, Giuseppe; Montalto, Massimo; Cammarota, Giovanni; Ricci, Riccardo; Masciana, Roberta; Forgione, Alessandra; Gabrieli, Maria; Perotti, Germano; Vecchio, Fabio; Rapaccini, Gian Ludovico; Gasbarrini, Giovanni; Day, Christopher; Grieco, Antonio. Increased Intestinal Permeability and Tight Junction Alterations in Non-Alcoholic Fatty Liver Disease (NAFLD). Hepatology, June 2009
  2. Bugianesi, Elisabetta; Vanni, Ester. The Gut-Liver Axis in Nonalcoholic Fatty Liver Disease (NAFLD): Another Pathway to Insulin Resistance? Hepatology, June 2009

Cite This Page:

Wiley-Blackwell. "Intestinal Bacteria Associated With Non-alcoholic Fatty Liver Disease." ScienceDaily. ScienceDaily, 31 May 2009. <www.sciencedaily.com/releases/2009/05/090528142833.htm>.
Wiley-Blackwell. (2009, May 31). Intestinal Bacteria Associated With Non-alcoholic Fatty Liver Disease. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2009/05/090528142833.htm
Wiley-Blackwell. "Intestinal Bacteria Associated With Non-alcoholic Fatty Liver Disease." ScienceDaily. www.sciencedaily.com/releases/2009/05/090528142833.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins