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New Way To Enhance Stem Cells To Stimulate Muscle Regeneration

Date:
June 7, 2009
Source:
Ottawa Hospital Research Institute
Summary:
Scientists have discovered a powerful new way to stimulate muscle regeneration, paving the way for new treatments for debilitating conditions such as muscular dystrophy. The research shows for the first time that a protein called Wnt7a increases the number of stem cells in muscle tissue, leading to accelerated growth and repair of skeletal muscle.

Scientists at the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa have discovered a powerful new way to stimulate muscle regeneration, paving the way for new treatments for debilitating conditions such as muscular dystrophy.

The research, to be published in the June 5 issue of Cell Stem Cell, shows for the first time that a protein called Wnt7a increases the number of stem cells in muscle tissue, leading to accelerated growth and repair of skeletal muscle.

"This discovery shows us that by targeting stem cells to boost their numbers, we can improve the body's ability to repair muscle tissue," said senior author Dr. Michael Rudnicki. Dr. Rudnicki is the Scientific Director of Canada's Stem Cell Network and a Senior Scientist at OHRI and Director of OHRI's Sprott Centre for Stem Cell Research, as well as a Professor of Medicine at the University of Ottawa.

Stem cells give rise to every tissue and organ in the body. Satellite stem cells are specialized muscle stem cells that live in adult skeletal muscle tissue and have the ability to both replicate and differentiate into various types of muscle cells. Dr. Rudnicki's team found that the Wnt7a protein, when introduced into mouse muscle tissue, significantly increased the population of these satellite stem cells and fueled the regeneration process, creating bigger and stronger muscles. Muscle tissue mass was increased by nearly 20 per cent in the study.

"Our findings point the way to the development of new therapeutic treatment for muscular diseases such as muscular dystrophy, sarcopenia and muscle wasting conditions resulting from extended hospital stays and surgeries," said Dr. Rudnicki.

This project was funded by the Canadian Institutes of Health Research, the Muscular Dystrophy Association, the National Institutes of Health, the Howard Hughes Medical Institute, Canada's Stem Cell Network and the Canada Research Chairs Program.


Story Source:

The above story is based on materials provided by Ottawa Hospital Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fabien Le Grand, Andrew E. Jones, Vanessa Seale, Anthony Scimè, Michael A. Rudnicki. Wnt7a Activates the Planar Cell Polarity Pathway to Drive the Symmetric Expansion of Satellite Stem Cells. Cell Stem Cell, 2009; DOI: 10.1016/j.stem.2009.03.013

Cite This Page:

Ottawa Hospital Research Institute. "New Way To Enhance Stem Cells To Stimulate Muscle Regeneration." ScienceDaily. ScienceDaily, 7 June 2009. <www.sciencedaily.com/releases/2009/06/090604124025.htm>.
Ottawa Hospital Research Institute. (2009, June 7). New Way To Enhance Stem Cells To Stimulate Muscle Regeneration. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2009/06/090604124025.htm
Ottawa Hospital Research Institute. "New Way To Enhance Stem Cells To Stimulate Muscle Regeneration." ScienceDaily. www.sciencedaily.com/releases/2009/06/090604124025.htm (accessed September 18, 2014).

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