Featured Research

from universities, journals, and other organizations

Lifespan Of HIV-infected Cells Might Be Shorter Than Previously Believed

Date:
July 3, 2009
Source:
NWO (Netherlands Organization for Scientific Research)
Summary:
Researchers have used mathematical models to demonstrate that cells infected with HIV could die sooner than was thought until now. If infected cells have a shorter lifespan then this increases the chances of the virus escaping the attention of the immune system.

Dutch-sponsored researcher Christian Althaus has used mathematical models to demonstrate that cells infected with HIV could die even sooner than was thought until now. If infected cells have a shorter lifespan then this increases the chances of the virus escaping the attention of the immune system.

Althaus used mathematical models and computer simulations to describe the dynamics of viral populations and immune responses. For example, he studied how chronic viral infections such as HIV are kept under control. The human immune system attempts to prevent the replication of viruses in various ways. The so-called cytotoxic T cells are capable of recognising and killing cells that have been infected with the virus. Althaus found that if cells are recognised and eliminated directly after infection before they start producing virus then the viral replication is considerably reduced.

Hiding from the immune response

Each time the virus infects a new cell it can change itself by mutating so that the newly infected cells are no longer recognised and destroyed. This process of 'immune escape' can reflect how strongly the immune system suppresses the virus. This is what led Althaus to study the speed at which these new and unrecognisable viral variants are generated and selected. He also found that HIV-infected cells might survive for a shorter period than expected until now, which means it is even more difficult for the immune system to recognise and destroy these cells.

This type of research is essential for an improved knowledge of viral infections. The models Althaus has developed provide a better understanding of why the immune system can sometimes effectively control viral infections and sometimes not. This opens up possibilities for further research into the immune system of people infected with HIV.

Christian Althaus has carried out this work as a member of Rob de Boer's research group. De Boer received a Vici grant from the NWO's Innovational Research Incentives Scheme in 2004. He aims to use this grant to set up a novel, quantitative approach to immunology.


Story Source:

The above story is based on materials provided by NWO (Netherlands Organization for Scientific Research). Note: Materials may be edited for content and length.


Cite This Page:

NWO (Netherlands Organization for Scientific Research). "Lifespan Of HIV-infected Cells Might Be Shorter Than Previously Believed." ScienceDaily. ScienceDaily, 3 July 2009. <www.sciencedaily.com/releases/2009/06/090630163326.htm>.
NWO (Netherlands Organization for Scientific Research). (2009, July 3). Lifespan Of HIV-infected Cells Might Be Shorter Than Previously Believed. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2009/06/090630163326.htm
NWO (Netherlands Organization for Scientific Research). "Lifespan Of HIV-infected Cells Might Be Shorter Than Previously Believed." ScienceDaily. www.sciencedaily.com/releases/2009/06/090630163326.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Ebola Patient Told Hospital He Was from Liberia

Ebola Patient Told Hospital He Was from Liberia

AP (Oct. 1, 2014) The first Ebola patient diagnosed in the U.S. initially went to a Dallas emergency room last week but was sent home, despite telling a nurse that he had been in disease-ravaged West Africa, the hospital acknowledged Wednesday. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins