Featured Research

from universities, journals, and other organizations

Lifespan Of HIV-infected Cells Might Be Shorter Than Previously Believed

Date:
July 3, 2009
Source:
NWO (Netherlands Organization for Scientific Research)
Summary:
Researchers have used mathematical models to demonstrate that cells infected with HIV could die sooner than was thought until now. If infected cells have a shorter lifespan then this increases the chances of the virus escaping the attention of the immune system.

Dutch-sponsored researcher Christian Althaus has used mathematical models to demonstrate that cells infected with HIV could die even sooner than was thought until now. If infected cells have a shorter lifespan then this increases the chances of the virus escaping the attention of the immune system.

Related Articles


Althaus used mathematical models and computer simulations to describe the dynamics of viral populations and immune responses. For example, he studied how chronic viral infections such as HIV are kept under control. The human immune system attempts to prevent the replication of viruses in various ways. The so-called cytotoxic T cells are capable of recognising and killing cells that have been infected with the virus. Althaus found that if cells are recognised and eliminated directly after infection before they start producing virus then the viral replication is considerably reduced.

Hiding from the immune response

Each time the virus infects a new cell it can change itself by mutating so that the newly infected cells are no longer recognised and destroyed. This process of 'immune escape' can reflect how strongly the immune system suppresses the virus. This is what led Althaus to study the speed at which these new and unrecognisable viral variants are generated and selected. He also found that HIV-infected cells might survive for a shorter period than expected until now, which means it is even more difficult for the immune system to recognise and destroy these cells.

This type of research is essential for an improved knowledge of viral infections. The models Althaus has developed provide a better understanding of why the immune system can sometimes effectively control viral infections and sometimes not. This opens up possibilities for further research into the immune system of people infected with HIV.

Christian Althaus has carried out this work as a member of Rob de Boer's research group. De Boer received a Vici grant from the NWO's Innovational Research Incentives Scheme in 2004. He aims to use this grant to set up a novel, quantitative approach to immunology.


Story Source:

The above story is based on materials provided by NWO (Netherlands Organization for Scientific Research). Note: Materials may be edited for content and length.


Cite This Page:

NWO (Netherlands Organization for Scientific Research). "Lifespan Of HIV-infected Cells Might Be Shorter Than Previously Believed." ScienceDaily. ScienceDaily, 3 July 2009. <www.sciencedaily.com/releases/2009/06/090630163326.htm>.
NWO (Netherlands Organization for Scientific Research). (2009, July 3). Lifespan Of HIV-infected Cells Might Be Shorter Than Previously Believed. ScienceDaily. Retrieved February 26, 2015 from www.sciencedaily.com/releases/2009/06/090630163326.htm
NWO (Netherlands Organization for Scientific Research). "Lifespan Of HIV-infected Cells Might Be Shorter Than Previously Believed." ScienceDaily. www.sciencedaily.com/releases/2009/06/090630163326.htm (accessed February 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, February 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
London Show Dissects History of Forensic Science

London Show Dissects History of Forensic Science

AFP (Feb. 25, 2015) Forensic science, which has fascinated generations with its unravelling of gruesome crime mysteries, is being put under the microscope in an exhibition of real criminal investigations in London. Duration: 00:53 Video provided by AFP
Powered by NewsLook.com
Michigan Couple Celebrates Identical Triplets

Michigan Couple Celebrates Identical Triplets

AP (Feb. 25, 2015) A suburban Detroit couple who have two older children are adjusting to life after becoming parents to identical triplets _ a multiple birth a doctor calls rare. (Feb. 25) Video provided by AP
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins