Featured Research

from universities, journals, and other organizations

Immune Protection Against Lethal Parasitic Disease

Date:
July 21, 2009
Source:
Journal of Clinical Investigation
Summary:
Kala azar is a lethal disease caused by infection with the protozoan parasite Leishmania donovani. Scientists have now obtained new insight into the human immune responses responsible for protection against kala azar.

Kala azar is a lethal disease caused by infection with the protozoan parasite Leishmania donovani. Alain Dessein and colleagues, at INSERM UMR 906, France, have now obtained new insight into the human immune responses responsible for protection against kala azar.

Although the immune molecules IL-17 and IL-22, which are produced by immune cells known as Th17 cells, provide protection against some bacteria and fungal pathogens in animal models, their role in protection against microbes has not been determined in humans. In this study, analysis of a subset of blood cells (peripheral blood mononuclear cells) from individuals who were infected with Leishmania donovani and developed kala azar and those who were infected with the protozoan parasite but did not develop kala azar showed that IL-17 and IL-22 were strongly and independently associated with resistance to kala azar.

Further analysis indicated that peripheral blood mononuclear cells from individuals who developed kala azar produced lower levels of the factors required for the induction of Th17 cells. As peripheral blood mononuclear cells from healthy individuals produced high levels of IL-17 and IL-22 when exposed to Leishmania donovani in vitro, the authors conclude that IL-17 and IL-22 have important complementary roles in protecting individuals from developing kala azar following infection with Leishmania donovani.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani. Journal Of Clinical Investigation, July 13, 2009

Cite This Page:

Journal of Clinical Investigation. "Immune Protection Against Lethal Parasitic Disease." ScienceDaily. ScienceDaily, 21 July 2009. <www.sciencedaily.com/releases/2009/07/090713201440.htm>.
Journal of Clinical Investigation. (2009, July 21). Immune Protection Against Lethal Parasitic Disease. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2009/07/090713201440.htm
Journal of Clinical Investigation. "Immune Protection Against Lethal Parasitic Disease." ScienceDaily. www.sciencedaily.com/releases/2009/07/090713201440.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins